Diaphragm type sample injection device

A sample introduction device and membrane type technology, which is applied in the field of liquid chromatography analysis instruments, and can solve the problems of reducing the area of ​​the membrane, limiting the sample loading amount, and the diffusion of the elution peak of the target object.

Active Publication Date: 2015-02-25
HUNAN DEMETER INSTR CO LTD
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Problems solved by technology

[0004] There is such a shortcoming in the above-mentioned tight-fitting system: because the eluting solution flows through the paper from the direction perpendicular to the plane of the paper in the said tight-fitting system, and the caliber of the eluting solution inlet is much smaller than the diameter of the paper, so The farther the distance from the center of the paper, the smaller the flow velocity of the eluting solution. Therefore, the samples distributed on the paper farther f

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0027] Such as Figure 1-2 As shown, a membrane-type sampling device includes an upper adapter 1 with a cavity inside, a lower adapter 2 matching the upper adapter and a membrane 5 placed between the upper adapter 1 and the lower adapter 2. A shunt 3 is provided in the inner cavity of the adapter 1, and there is a gap with a distance of ≤2 mm between the shunt 3 and the inner wall of the upper adapter, and the lower end of the shunt 3 protrudes from the inner cavity of the upper adapter 1, and the protruding part is in contact with the inner wall of the upper adapter. The diaphragm 5 is bonded.

[0028] The flow divider 3 is preferably a cylinder, and at least two protrusions 4 are preferably provided on the periphery of the cylinder, and the flow divider 3 is engaged in the inner cavity of the upper adapter 1 through the protrusions 4 .

[0029] A me...

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Abstract

The invention belongs to the field of a liquid phase chromatography analysis instrument, and in particular relates to a diaphragm type sample injection device. The diaphragm sample injection device comprises an upper adaptor (1) internally provided with a cavity, a lower adaptor (2) which is matched with the upper adaptor, and a diaphragm (5) which is arranged between the upper adaptor (1) and the lower adaptor (2); and the diaphragm sample injection device also comprises a shunt (3) which is arranged in the inner cavity of the upper adaptor (1), the shape of the shunt (3) is matched with the shape of the inner cavity of the upper adaptor, a gap which is less than or equal to 2mm is formed between the shunt (3) and the inner wall of the upper adaptor, and at least one bulge is arranged in the gap to be used for connecting the shunt and the inner wall of the upper adaptor. By adopting the diaphragm type sample injection device, the diffusion factor of elution is reduced through the axial and radial transformation of an elution solution, and the sample carrying area of the diaphragm is increased.

Description

technical field [0001] The invention belongs to the field of liquid chromatography analysis instruments, and in particular relates to a membrane type sampling device. Background technique [0002] In liquid chromatography analysis, the sample injection method is usually to inject the sample solution into the quantitative loop and connect it to the liquid chromatography system through a switching valve, so the sample must be in a solution state before it can be injected. However, many substances are prone to decomposition, adsorption and conversion in solution, which is not conducive to long-term storage and storage. Therefore, a liquid chromatography sampling method that is conducive to stable storage of samples is needed. [0003] There is a literature report on a dry blood spot (dried blood spot, DBS) technology combined with liquid chromatography, the process is to drop the sample (such as blood, biological fluid, etc.) on a circular paper, The sample is evaporated or b...

Claims

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Application Information

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IPC IPC(8): G01N30/18
Inventor 王峰肖轶雯李焕德张国余
Owner HUNAN DEMETER INSTR CO LTD
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