Organic metal rhodium compound and preparation method and application thereof

A rhodium compound, organometallic technology, applied in the field of organometallic rhodium compound and its preparation, to achieve the effect of simple preparation method, low cost, and good inhibition of tumor cell activity

Inactive Publication Date: 2015-04-01
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on rhodium complexes with curcuminoids as the main ligand

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  • Organic metal rhodium compound and preparation method and application thereof
  • Organic metal rhodium compound and preparation method and application thereof
  • Organic metal rhodium compound and preparation method and application thereof

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preparation example Construction

[0032] A preparation method of an organometallic rhodium compound, comprising the following steps:

[0033] Step 1. Dissolve 2,4-pentanedione, 3,4-dimethoxybenzaldehyde and diboron trioxide together in pure DMF solution, and react at 70-90°C for 5-7 hours under the protection of nitrogen, preferably Under the protection of nitrogen, react at 80°C for 6 hours, add hydrochloric acid, and leave to precipitate to obtain (1E,3Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxyl-1,3, 6-heptatrien-5-one, the structural formula is as follows:

[0034]

[0035] Step 2, the p-dimethylaminobenzaldehyde and the (1E,3Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxyl-1,3,6- Heptatrien-5-one is dissolved in pure toluene, mixed with pure acetic acid, reacted at 100-200°C for 5-10h, preferably at 150°C for 8h, and (1E,6E)-1,7-di (3,4-dimethoxyphenyl)-4-(p-methylaminophenylvinyl)-1,6-heptadiene-2,5-dione, the structural formula is as follows:

[0036]

[0037] Step 3, (1E, 6E)-1,7-bis(3,4-dimethoxy...

Embodiment 1

[0044] 1. Product preparation

[0045] Dissolve 0.095g of 2,4-pentanedione, 0.12g of 3,4-dimethoxybenzaldehyde and 1mmol of boron trioxide in 10ml of DMF solution, react at 80°C for 6 hours under the protection of nitrogen, and then add 8ml of 0.5M Hydrochloric acid, standing and precipitating to obtain (1E, 3Z, 6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxyl-1,3,6-heptatrien-5-one; 20 mg of p-dimethylaminobenzaldehyde and 40 mg of (1E,3Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxy-1,3,6-heptanetri En-5-one was dissolved in 10ml of toluene, added 0.5mg of acetic acid, reacted at 150oC for 8h, and (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(p- (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)- 4-(p-methylaminophenylvinyl)-1,6-heptadiene-2,5-dione and 40 mg dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer were dissolved in 8ml of dichloromethane, heated, stirred and refluxed for 16 hours. After the reaction was completed, the solution was evaporated to leave 3ml of liquid, and 15ml of eth...

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Abstract

The invention discloses an organic metal rhodium compound and a preparation method and application thereof. The organic metal rhodium compound is chlorine-(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(p-methylamino phenyl vinyl)-1,6-heptadiene-2,5-diketone-pentamethyl cyclopentadienyl rhodium (III). The organic metal rhodium compound can be applied to preparation of a drug for treating cancer and resisting bacteria. The structural formula of the organic metal rhodium compound is shown in the specification.

Description

technical field [0001] The invention relates to the field of chemical medicine, in particular to an organometallic rhodium compound and its preparation method and application. technical background [0002] Metal complexes are widely used in medical and health care, such as cisplatin, which is one of the three most widely used drugs to treat cancer in the world. Cisplatin is a heavy metal compound that can act on tumor cells However, cisplatin has a variety of side effects, such as nephrotoxicity, peripheral neurotoxicity, bone marrow toxicity, hematological toxicity, and emetics. Therefore, the present invention intends to explore a cisplatin substitute rhodium metal complex, rhodium and platinum are both heavy metals, whether its complex has the same anti-cancer effect as cisplatin, currently the rhodium metal complex There are still few studies, but the existing research basis shows that the development of rhodium metal complexes in medicine has great potential. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61K31/28A61P35/00A61P31/10
CPCC07F15/008
Inventor 李培源苏炜霍丽妮陈睿
Owner GUANGXI UNIV OF CHINESE MEDICINE
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