Rhodium metal curcumin compound as well as preparation method and application thereof

A technology of curcumin and compounds, applied in the field of rhodium metal curcumin compounds and their preparation, to achieve the effects of extensive prevention and treatment, simple preparation method, and easy-to-obtain raw materials

Inactive Publication Date: 2015-03-11
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on rhodium complexes with curcuminoids as the main ligand

Method used

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  • Rhodium metal curcumin compound as well as preparation method and application thereof
  • Rhodium metal curcumin compound as well as preparation method and application thereof
  • Rhodium metal curcumin compound as well as preparation method and application thereof

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preparation example Construction

[0032] A kind of preparation method of rhodium metal curcumin compound, wherein, comprises the following steps:

[0033] Step 1. Dissolve 2,4-pentanedione, 3,4-dimethoxybenzaldehyde and diboron trioxide in a DMF solution with a concentration of 80-100%, and react at 70-90°C under nitrogen protection for 5-7 Hours, preferably after reacting at 80°C for 6 hours under the protection of nitrogen, then mix with hydrochloric acid, and leave to precipitate to obtain (1E, 3Z, 6E)-1,7-bis(3,4-dimethoxyphenyl )-3-hydroxyl-1,3,6-heptatrien-5-one, the structural formula is as follows:

[0034]

[0035] Step 2, triethyl orthoformate and the (1E,3Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxyl-1,3,6-heptyl Trien-5-one is dissolved in toluene with a concentration of 80-100%, mixed with acetic acid with a concentration of 80-100%, reacted at 100-200°C for 5-10h, preferably at 150°C for 8 hours, and allowed to stand (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-hydroxyvinyl-1,6-heptadiene-2,5-dion...

Embodiment 1

[0044] 1. Product preparation

[0045] Dissolve 0.095g of 2,4-pentanedione, 0.12g of 3,4-dimethoxybenzaldehyde and 1mmol of boron trioxide in 10ml of DMF solution, react at 80°C for 6 hours under the protection of nitrogen, and then add 8ml of 0.5M Hydrochloric acid, standing and precipitating to obtain (1E, 3Z, 6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxyl-1,3,6-heptatrien-5-one; 100 mg of triethyl orthoformate and 40 mg of the (1E,3Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-3-hydroxyl-1,3,6-heptanetri En-5-one was dissolved in 10ml of toluene, added 0.5mg of acetic acid, reacted at 150°C for 8 hours, and (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)- 4-Hydroxyvinyl-1,6-heptadiene-2,5-dione; 30mg (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-hydroxy Vinyl-1,6-heptadiene-2,5-dione and 40 mg of dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer were dissolved in 8 ml of dichloromethane, heated and stirred under reflux for 16 After the reaction was completed, the solution was evaporated to 3ml ...

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Abstract

The invention discloses a rhodium metal curcumin compound as well as a preparation method and application thereof. The compound is monochloride-(1E,6E)-1,7-di(3,4-dimethoxyphenyl)-4-hydroxy vinyl-1,6-heptadiene-2,5-diketone-pentamethyl cyclopentadienyl rhodium (III), and the compound can serve as the application for preparing drugs for treating cancers and resisting parasites. The structural formula of the compound is shown in the Specification.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to a rhodium metal curcumin compound and its preparation method and application. technical background [0002] In recent years, metal compounds have played an increasingly important role in the fields of medical treatment and hygiene. We know that cisplatin is a platinum compound, and now cisplatin has become one of the three most widely used drugs for cancer treatment in the world, but cisplatin has many side effects, such as nephrotoxicity, peripheral neurotoxicity, bone marrow toxicity, blood Toxicity and emetics etc. Therefore, it has become a new research direction to explore and develop new metal compounds while maintaining the same drug effect and reduce the side effects of metal compounds as much as possible. It is still unknown whether the compounds of rhodium, which is also a rare metal, have the same drug effect. However, the existing research basis shows that the deve...

Claims

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Application Information

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IPC IPC(8): C07F17/02A61P35/00A61P33/00A61P33/06A61P31/04A61P31/10
CPCC07F17/02
Inventor李培源苏炜霍丽妮陈睿
OwnerGUANGXI UNIV OF CHINESE MEDICINE