Metal rhodium compound as well as preparation method and application thereof

A rhodium compound and metal technology, applied in the field of metal rhodium compounds and their preparation, achieves the effects of good insecticidal effect, cost reduction and low cost

Active Publication Date: 2015-04-01
陕西专壹知识产权运营有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on rhodium complexe

Method used

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  • Metal rhodium compound as well as preparation method and application thereof
  • Metal rhodium compound as well as preparation method and application thereof
  • Metal rhodium compound as well as preparation method and application thereof

Examples

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Example Embodiment

[0031] A method for preparing a metal rhodium compound, which comprises the following steps:

[0032] Step 1. Dissolve 2,4-pentanedione, 3-methoxy-4-hydroxybenzaldehyde, and boron trioxide in a DMF solution with a concentration of 90-100%, preferably a pure DMF solution, 70- under nitrogen protection. After reacting at 90°C for 5-7 hours, of which 80°C and 6 hours are preferred, it is then mixed with hydrochloric acid and allowed to stand and precipitate to obtain (1E, 3Z, 6E)-1,7-bis(3-methoxy-4-hydroxybenzene) Group)-3-hydroxy-1,3,6-heptatrien-5-one, the structural formula is as follows:

[0033]

[0034] Step 2. Combine p-ethylbenzaldehyde with (1E, 3Z, 6E)-1,7-bis(3-methoxy-4-hydroxyphenyl)-3-hydroxy-1,3,6-heptatriene -5-one is dissolved in toluene with a concentration of 90-100%, preferably pure toluene, and then mixed with acetic acid with a concentration of 90-100%, of which pure acetic acid is preferred, and the reaction is performed at 100-150°C for 5-10 hours, of which 1...

Example Embodiment

[0042] Example 1

[0043] 1. Product preparation

[0044] Weigh out 0.095g of 2,4-pentanedione, 0.12g of 3-methoxy-4-hydroxybenzaldehyde, and 1mmol of diboron trioxide in 10ml of DMF solution. After reacting at 80℃ for 6 hours under nitrogen protection, add 8ml 0.5M hydrochloric acid, standing to precipitate to obtain (1E,3Z,6E)-1,7-bis(3-methoxy-4-hydroxyphenyl)-3-hydroxy-1,3,6-heptatriene-5 -Ketone; 20 mg of p-ethylbenzaldehyde and 40 mg of (1E, 3Z, 6E)-1,7-bis(3-methoxy-4-hydroxyphenyl)-3-hydroxy-1,3,6 -Heptatrien-5-one was dissolved in 10ml of toluene, 0.5mg of acetic acid was added, and the reaction was carried out at 150°C for 8 hours. After standing still, (1E, 6E)-1,7-bis(3-methoxy-4-hydroxyphenyl) -4-(p-ethylphenylvinyl)-1,6-heptadiene-2,5-dione; 30mg of (1E,6E)-1,7-bis(3-methoxy-4 -Hydroxyphenyl)-4-(p-ethylphenylvinyl)-1,6-heptadiene-2,5-dione and 40mg dichloro(pentamethylcyclopentadienyl) rhodium(III) ) The dimer was dissolved in 8ml of dichloromethane, heated and st...

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Abstract

The invention discloses a metal rhodium compound as well as a preparation method and application thereof. The rhodium compound is monochloro-(1E,6E)-1,7-bis(3-methoxy-4-hydroxyphenyl)-4-(p-ethyl phenyl vinyl)-1,6-heptadiene-2,5-dione-pentamethyl cyclopentadienyl rhodium (III), and the rhodium compound can be used for preparing anticancer and antiparasite medicines. The rhodium compound has a structural formula as shown in the specification.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to a metal rhodium compound and its preparation method and application. technical background [0002] Cisplatin is a heavy metal complex, which is one of the three most widely used drugs for cancer treatment in the world. Cisplatin can inhibit the replication process of cellular DNA, and at high concentrations can inhibit the synthesis of RNA and protein. When used to treat cancer, it can inhibit the replication of tumor cells and damage the structure of cell membranes, thereby killing tumor cells. Rhodium metal complexes and cisplatin are both heavy metal complexes, which, like cisplatin, can inhibit the replication of tumor cells. At present, there are few studies on rhodium metal complexes, but the existing research basis shows that rhodium metal complexes The development of compounds in medicine has great potential. [0003] Curcumin compounds have the effects of lowering blo...

Claims

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Application Information

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IPC IPC(8): C07F15/00A61K31/28A61P33/06A61P35/00
CPCC07F17/02
Inventor 李培源苏炜霍丽妮陈睿
Owner 陕西专壹知识产权运营有限公司
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