A detection method for forsythia and products containing forsythia

A detection method and technology of forsythia, applied in measuring devices, instruments, scientific instruments, etc., can solve the problem of being unable to identify the authenticity of medicines containing forsythia

Active Publication Date: 2016-04-20
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0029] From the above content, it can be seen that the detection of the existing forsythia or products containing forsythia is mostly carried out with forsythin and forsythiaside A as the main components, which leads some unscrupulous traders to replace forsythia with forsythia leaves containing forsythia Feeding, the existing standards cannot identify the authenticity of medicines containing forsythia

Method used

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  • A detection method for forsythia and products containing forsythia
  • A detection method for forsythia and products containing forsythia
  • A detection method for forsythia and products containing forsythia

Examples

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Embodiment 1

[0068] Example 1: Detection of penicillin in Shuanghuanglian Oral Liquid

[0069] 1. Instruments and experimental drugs

[0070] Instrument: Agilent1100 high performance liquid chromatograph, equipped with degasser, quaternary gradient pump, autosampler, column thermostat, diode array detector, ultraviolet detector (Agilent).

[0071] Reagents: acetonitrile and methanol were chromatographically pure (Merck Company), formic acid was chromatographically pure (ROCScientific Company), and water was Milli-Q ultrapure water.

[0072] Penicillin (HPLC purity: 99.24%) is made by the Pharmaceutical Informatics Laboratory of Zhejiang University; ),China Institute of Food and Drug test.

[0073] Shuanghuanglian oral liquid (provided by Heilongjiang Zhenbaodao Pharmaceutical Co., Ltd., batch number: B20140412, B20140413, B20140414, S130724-1, S130724-2, S130724-3, S130724-4, S130724-5, S130724-6, S130802-1 );

[0074] Shuanghuanglian oral liquid prepared from forsythia leaves (provide...

Embodiment 2

[0093] Embodiment 2: the detection of Shuanghuanglian injection

[0094] With the method of embodiment 1.

Embodiment 3

[0095] Example 3: Detection of Xiaoer Resuqing Syrup and Compound Qinlan Oral Liquid

[0096] With the method of embodiment 1.

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Abstract

The invention relates to a detection method for Forsythia suspensa and a product containing Forsythia suspensa. Adoxosidic acid is used as a reference substance; alternatively, a forsythin reference substance is used as a substitute for adoxosidic acid, and the adoxosidic acid content is calculated through correction factors. To sell seconds at best quality prices, some merchants of the conventional product replace Forsythia suspensa fruits with Forsythia suspensa leaves, which results in unsatisfactory effects of the final product. According to an accidental discovery of the inventor, Forsythia suspensa leaves do not contain adoxosidic acid, and the quality validity for the product containing Forsythia suspensa can be controlled through adoxosidic acid detection, so that the quality of the product containing Forsythia suspensa can be guaranteed.

Description

technical field [0001] The invention relates to the field of detection methods of traditional Chinese medicines, in particular to a detection method for forsythia and products containing forsythia. Background technique [0002] Forsythia is one of the traditional Chinese medicines commonly used in clinical practice in China. It is also known as Huanghuatiao, Lianhu, Qingqiao, Luoqiao, Huangqidan, etc. The fruit is used as medicine. Forsythia is a traditional Chinese medicine for clearing away heat and detoxifying. It is mainly used to treat the initial onset of febrile disease, wind-heat cold, fever, upset, sore throat, acute nephritis, etc. [0003] The medicinal part of Forsythia is the dried fruit of Forsythiasuspensa (Thunb.) Vahl. Harvest in autumn when the fruit is still green at first ripeness, remove impurities, steam it, and dry it in the sun. [0004] In the 2010 edition of "Chinese Pharmacopoeia", there are detection methods for the content of forsythia extract ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G01N30/02
Inventor方同华邵青葛志伟岳大彪许照芹周广红席桂才代喜国王倩冯慧贾文娟
OwnerHEILONGJIANG ZBD PHARMA