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Pharmaceutical composition for treating and preventing depression and preparation method of pharmaceutical composition

A composition and technology for depression, which can be used in drug combinations, pharmaceutical formulations, and medical preparations without active ingredients, etc., and can solve problems such as difficult quality control, unclear active ingredients, and complex composition.

Inactive Publication Date: 2015-04-08
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Both clinical use and experimental research have shown that the traditional Chinese medicine compound Xiaoyao San and its effective parts have better antidepressant effects, but the prescription is composed of 8 medicinal materials: Bupleurum, Angelica, Atractylodes Rhizoma, Radix Paeoniae Alba, Poria, Licorice, Ginger, and Mint. Complex, the active ingredients are not yet clear, the quality is not easy to control, and it is inconvenient for patients to take it

Method used

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  • Pharmaceutical composition for treating and preventing depression and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating and preventing depression and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating and preventing depression and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of pharmaceutical composition for treatment and prevention of depression:

[0019] Weigh the Radix Bupleurum medicinal material, crush it, use 10 times the amount of 80% ethanol solution for microwave-assisted extraction for 3 times, each time for 40 minutes, extract the extract with an equal volume of water-saturated n-butanol, evaporate the n-butanol, add ether, and precipitate. Filter to get Bupleurum extract;

[0020] Weigh the medicinal material of Angelica sinensis, pulverize it, use 10 times the amount of 70% ethanol solution for microwave-assisted extraction three times, each time for 40 minutes, evaporate the ethanol, and dry to obtain the angelica extract;

[0021] Weigh Atractylodes macrocephala medicinal material, pulverize it, use 10 times the amount of 70% ethanol solution for microwave-assisted extraction three times, each time for 40 minutes, evaporate the ethanol, and dry to obtain Atractylodes macrocephala extract.

[0022] Take 300 g of B...

Embodiment 2

[0024] Preparation of pharmaceutical composition for treatment and prevention of depression:

[0025] The preparation of Bupleurum extract, Angelica sinensis extract and Atractylodes macrocephala extract is the same as in Example 1.

[0026] Take 600g of Bupleurum extract, 300g of Angelica sinensis extract and 300g of Atractylodes macrocephala extract prepared above and mix them evenly.

Embodiment 3

[0028] Preparation of pharmaceutical composition for treatment and prevention of depression:

[0029] The preparation of Bupleurum extract, Angelica sinensis extract and Atractylodes macrocephala extract is the same as in Example 1.

[0030] Take 300g of Bupleurum extract, 600g of Angelica sinensis extract and 300g of Atractylodes macrocephala extract prepared above and mix them evenly.

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Abstract

The invention discloses a pharmaceutical composition for treating and preventing depression and a preparation method of the pharmaceutical composition. The composition consists of radix bupleuri extract, Chinese angelica extract and white atractylodes rhizome extract. According to the pharmacological experiment results, the pharmaceutical composition can be used for obviously reducing dead time in a mouse forced swimming test and a mice hanging test, remarkably increasing chronic temperature and the weight and the sweet water eccentricity of an unpredictable depression model, and has an obvious anti-depression effect which can reach or exceed that of the existing clinical common anti-depression drugs.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating and preventing depression, a preparation method and application thereof. Background technique [0002] Depression is a mental disease that seriously endangers human health. After the illness, the main manifestations are depression, loss of interest, slow thinking, lack of initiative, pessimistic attitude towards things, anorexia, insomnia, and even suicide in severe cases. Moreover, depression has the characteristics of high incidence rate, high recurrence rate, and high disability rate. The incidence rate in my country is 2.5%, and the number of patients exceeds 30 million. [0003] At present, the drugs used to treat depression are mainly chemical drugs. For example, the "five golden flowers" that are called antidepressants by the psychiatric circles in my country are: fluoxetine (Prozac), paroxetine ( Sertraline), sertraline (Zoloft), f...

Claims

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Application Information

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IPC IPC(8): A61K36/284A61P25/24
CPCA61K36/233A61K9/1652A61K9/2059A61K9/28A61K36/232A61K36/284A61K47/34A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 田俊生张潇张丽增秦雪梅高晓霞周玉枝马开庆
Owner SHANXI UNIV
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