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A kind of nutria tail collagen surgical suture and its preparation method

A technique of surgical suture and nutria tail, which is applied in the field of medical surgical suture materials, can solve the problems of short length and achieve the effects of stable and reliable absorption, high tensile strength, and light tissue reaction

Active Publication Date: 2017-04-26
HEILONGJIANG LIHAIXIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using the natural collagen spinning solution extracted from nutria tail tendons by enzymatic digestion as raw material, it is reshaped into continuous collagen fiber filaments by solution wet spinning technology, and a new type of medical surgical suture material is made. In order to solve the shortcoming that the length is too short during its use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take the spare beaver tail tendon out of the refrigerator, cut it into thin slices with a thickness of 1-2mm, weigh 500g, rinse it with distilled water for 3 times, decant it, then add 0.5g of ficin, the ratio of ficin to tail tendon mass 0.1%, add 8000mL of distilled water, incubate in an incubator at 37°C for 8 hours, take it out and rinse with distilled water for 3-4 times, then add 500mL of distilled water and 5mL of H 2 o 2 , kill the enzyme at room temperature for 20 minutes. The enzyme-killed slices were rinsed with distilled water for 3-4 times, and then 10000 mL of acetic acid solution with a mass concentration of 0.1% was added to swell for 8 hours. Fully stir the swollen flakes with a high-shear disperser for 2 hours, filter with an 80-mesh stainless steel mesh to remove impurities and non-swellable substances, and centrifuge for 30 minutes in a low-temperature centrifuge at 3000 rpm to obtain a spinning stock solution. Then the prepared collagen spinning s...

Embodiment 2

[0024] Take the spare beaver tail tendon out of the refrigerator, cut it into thin slices with a thickness of 1-2mm, weigh 500g, rinse it with distilled water for 3 times, decant it, then add 0.5g of ficin, the ratio of ficin to tail tendon mass 0.1%, add 8000mL of distilled water, incubate in an incubator at 37°C for 8 hours, take it out and rinse it with distilled water for 3 times, then add 500mL of distilled water and 5mL of H 2 o 2 , kill the enzyme at room temperature for 20 minutes. The enzyme-killed slices were rinsed with distilled water for 3-4 times, and then 10000 mL of acetic acid solution with a mass concentration of 0.1% was added to swell for 8 hours. Fully stir the swollen flakes with a high-shear disperser for 2 hours, filter with an 80-mesh stainless steel mesh to remove impurities and non-swellable substances, and use a low-temperature centrifuge at 3000 rpm for degassing for 30 minutes to obtain a spinning stock solution. Then the prepared collagen spinn...

Embodiment 3

[0028]Take the spare beaver tail tendon out of the refrigerator, cut it into thin slices with a thickness of 1-2mm, weigh 500g, rinse it with distilled water for 3 times, decant it, then add 0.5g of ficin, the ratio of ficin to tail tendon mass 0.1%, add 8000mL of distilled water, incubate in an incubator at 37°C for 8 hours, take it out and rinse it with distilled water for 3 times, then add 500mL of distilled water and 5mL of H 2 o 2 , kill the enzyme at room temperature for 20 minutes. The enzyme-killed slices were rinsed with distilled water for 3-4 times, and then 10000 mL of acetic acid solution with a mass concentration of 0.1 was added to swell for 8 hours. Fully stir the swollen flakes with a high-shear disperser for 2 hours, filter with an 80-mesh stainless steel mesh to remove impurities and non-swellable substances, and centrifuge for 30 minutes in a low-temperature centrifuge at 3000 rpm to obtain a spinning stock solution. Then the prepared collagen spinning so...

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Abstract

The invention discloses a nutria tail collagen surgical suture and a preparation method thereof. The method comprises the following steps: cutting standby nutria tail tendons into thin pieces, performing enzyme treatment by a ficus proteinase solution, preparing extracted natural collagen into a spinning solution, performing forming through a solution wet-spinning technology, and performing cross-linking to prepare the nutria tail collagen surgical suture which is a continuous long filament. The surgical suture has the diameter of 0.118-0.135 mm, the knot strength of 450-510 g and the elongation rate of 10.1-12.3%. The surgical suture meets the requirements of American suture size 6 / 0 and is suitable for clinical suturing. Biological experiments and clinical trials prove that the nutria tail collagen surgical suture has various advantages of mild tissue reaction, naturalness, degradability, non-toxicity, stability and reliability for absorption, high tensile strength, no need of being taken out, capability of being naturally absorbed or naturally falling off, no irritation, no scars after wound healing, and the like.

Description

technical field [0001] The invention belongs to medical surgical suture materials, and relates to a coypu tail collagen surgical suture thread and a preparation method thereof. Background technique [0002] At present, the surgical sutures used at home and abroad mainly include catgut, silk thread, nylon thread, polyglycolide (PGA), polylactic acid (PLA), polydioxanone (PDS) and collagen suture Wait. After using these sutures for surgical suturing, some of them cannot be absorbed naturally and need to be removed; Collagen sutures are made from mammalian bones, skin and tendons, and have the characteristics of natural degradability, non-toxicity, stable and reliable absorption, high tensile strength, and good biocompatibility. Its antigenicity is quite low, and it has excellent platelet aggregation performance, good hemostatic effect, and can promote cell growth. It is the most ideal suture material so far. [0003] Patent Publication Nos. CN1051510 and CN 1125622 respecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/08
Inventor 张志平丁长坤杨宁程博闻
Owner HEILONGJIANG LIHAIXIN BIOTECH CO LTD
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