The invention relates to the technical field of polytetrafluoroethylene microporous plates, in particular to a multifunctional expanded polytetrafluoroethylene plate and a lamination composite preparation process thereof. The polytetrafluoroethylene plate is made by mixing polytetrafluoroethylene, polytetrafluoroethylene modified material, fiber material, titanium dioxide and organic solvent evenly, pre-pressing and forming, extruding the bar, and pressing it into a film by twin-screw, then heating and volatilizing. The organic solvent is removed, and the polytetrafluoroethylene microporous film is obtained by horizontal and longitudinal stretching, and the polytetrafluoroethylene microporous film is made into a multifunctional polytetrafluoroethylene plate with high tensile strength through a lamination and composite process. The invention has low preparation cost, simple preparation process, good sealing, chemical stability, thermal stability and electrical insulation, as well as good creep resistance, tensile strength and antibacterial properties.