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Manufacturing method of medical absorpable suture

A technology of sutures and copolymers, which is applied in the field of preparation of medical absorbable sutures, can solve the problems of poor flexibility of collagen threads, poor knot stability, and weak ligation of sutures, and achieve high retained fracture strength, Wound healing with small scars and good elasticity

Inactive Publication Date: 2008-06-11
吉林金源北方科技发展有限公司
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  • Abstract
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Problems solved by technology

However, the degradation of collagen thread in the body is "hydrolysis" first, that is, the solubilization of water and then degradation, which is easy to cause suture swelling and make the suture ligation not firm
In addition, the flexibility of the collagen thread is not good, and the tensile strength is rapidly depleted in the environment of digestive fluid and infection, and sometimes there will be weak points and fiber tears on the suture line
Polyglycolic acid sutures spun from polyglycolide (PGA) and polylactide glycolic acid sutures spun from polyglycolide (PGLA) have the advantages of absorbability and light tissue reaction. However, there are also disadvantages of poor knot stability and weak knots, so it is necessary to tie a few more knots than ordinary silk sutures during surgery.

Method used

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  • Manufacturing method of medical absorpable suture
  • Manufacturing method of medical absorpable suture
  • Manufacturing method of medical absorpable suture

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preparation example Construction

[0014] A preparation method of medical absorbable suture:

[0015] (1) It takes carbon dioxide copolymer as raw material, and the structural formula of carbon dioxide copolymer is:

[0016]

[0017] x=0.5-1.0

[0018] R = H, CH 3 ,

[0019] n is an integer between 200 and 5,000, corresponding to a number average molecular weight between 20,000 and 500,000.

[0020] The above-mentioned carbon dioxide copolymer of the present invention can be carbon dioxide-ethylene oxide copolymer, or carbon dioxide-propylene oxide copolymer, or carbon dioxide-oxidized cyclohexane copolymer, or carbon dioxide-oxidized styrene copolymer, or carbon dioxide-epoxy Propane-cyclohexane terpolymer, or one or both of carbon dioxide-propylene oxide-ethylene oxide terpolymer.

[0021] The preparation method of the above-mentioned carbon dioxide copolymer of the present invention is the same as the method disclosed in 98125655.4 and 00136189.9, and will not be described in detail here.

[0022] ...

Embodiment 1

[0032] The carbon dioxide copolymer (carbon dioxide-propylene oxide unit content 58%, number average molecular weight 21000, molecular weight distribution index 4.2) was melted at 120°C, and 4wt% maleic anhydride was added to the copolymer weight to blend and granulate. The granulated carbon dioxide copolymer is spun by a spinning machine or melted at 155 ° C. After removing air bubbles, it passes through a spinneret with a hole diameter of 4 mm, and forms fibers of 2 mm after preliminary drafting. Secondary stretching was carried out in a water bath at ℃ to prepare a 2-0 suture with a strength of 26.50N.

Embodiment 2

[0034] The carbon dioxide copolymer (carbon dioxide-propylene oxide unit content 100%, number average molecular weight 198000, molecular weight distribution index 5.3) was melted at 150°C, and 1.2wt% of maleic anhydride based on the weight of the copolymer was added to blend and granulate. The granulated carbon dioxide copolymer is spun by a spinning machine or melted at 160 ° C. After removing air bubbles, it passes through a spinneret with a hole diameter of 6 mm, and is initially drawn to form a primary fiber of 4 mm. Secondary stretching was carried out in a water bath at 25°C to prepare a 6-0 suture with a strength of 2.50N.

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Abstract

An absorptive medical suture with high strength, toughness, biocompatibility and absorptivity, and abvious body temp memory effect is prepared from CO2 copolymer through fusing, mixing with maleic acid anhydride or acetic acid anhydride, granulating, fusing, mixing with polylactic acid or polyhydroxy butyrate, extruding for granulating, melt spinning and drafting in water bath.

Description

technical field [0001] The invention relates to a preparation method of a medical material, in particular to a preparation method of a medical absorbable suture. Background technique [0002] We know that medical absorbable sutures are the development trend of medical sutures today and have important application prospects. At present, there are mainly catgut, collagen thread, and biodegradable synthetic polymer suture such as polylactic acid thread. The main requirements of absorbable medical sutures are small tissue reaction, small wound scars, controllable absorption time, and easy knotting. Sheep catgut is an absorbable suture commonly used in China at present, but there are problems such as high brittleness of suture, length limited by the length of sheep intestine, strength of catgut related to the age of individual animals, and unsatisfactory knot performance. Chinese Invention Patent Publication No. CN1371919A discloses a method for preparing human collagen surgical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10D01F8/04
Inventor 冯超
Owner 吉林金源北方科技发展有限公司
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