Preparation method of polyglycolic acid methyl ester absorbable surgical suture

A technology of polymethyl glycolate and methyl glycolate is applied in the directions of surgery, single-component copolyester rayon, medical science, etc. Small healing scars, good knotting performance, and mild tissue reaction

Active Publication Date: 2018-10-02
JIANGSU JINJU ALLOY MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the regular and dense ester group structure in the molecular chain, the fiber obtained by melt spinning of polyglycolic acid methyl ester or polyglycolic acid has a relatively high hardness and a rough thread body, making it difficult to be used as a surgical suture material

Method used

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  • Preparation method of polyglycolic acid methyl ester absorbable surgical suture
  • Preparation method of polyglycolic acid methyl ester absorbable surgical suture
  • Preparation method of polyglycolic acid methyl ester absorbable surgical suture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] At first, methyl glycolate copolymer adopts following method to prepare:

[0030] 100 mol of methyl glycolate, 0.2 mol of adipic acid, and 0.2 mol of butanediol were added to the polymerization reactor, and precondensation was carried out at a stirring speed of 150 rpm and in the presence of a polymerization catalyst. Wherein, the polymerization catalyst is a mixture prepared by titanium isopropoxide and taurine in a mass ratio of 2:1, and the amount of the polymerization catalyst is 0.1% of the total mass of methyl glycolate. The precondensation temperature is 130-190° C., the reaction time is 8 hours, and the precondensation product is obtained. Under the stirring condition of 150 rev / min, the polycondensation product is subjected to polycondensation reaction to prepare methyl glycolate copolyester, the polycondensation temperature is 180-235° C., the reaction time is 12 hours, and the vacuum degree is 0.1-100 mmHg. The methyl glycolate copolymer obtained by polycond...

Embodiment 2

[0033] At first, methyl glycolate copolymer adopts following method to prepare:

[0034]100 mol of methyl glycolate, 0.2 mol of adipic acid, and 0.2 mol of butanediol were added to the polymerization reactor, and precondensation was carried out at a stirring speed of 150 rpm and in the presence of a polymerization catalyst. Wherein, the polymerization catalyst is a mixture prepared by titanium isopropoxide and taurine in a mass ratio of 2:1, and the amount of the polymerization catalyst is 0.1% of the total mass of methyl glycolate. The precondensation temperature is 130-190° C., the reaction time is 8 hours, and the precondensation product is obtained. Under the stirring condition of 150 rev / min, the polycondensation product is subjected to polycondensation reaction to prepare methyl glycolate copolyester, the polycondensation temperature is 180-235° C., the reaction time is 12 hours, and the vacuum degree is 0.1-100 mmHg. The methyl glycolate copolymer obtained by polyconde...

Embodiment 3

[0037] At first, methyl glycolate copolymer adopts following method to prepare:

[0038] 100 mol of methyl glycolate, 0.2 mol of adipic acid, and 0.2 mol of butanediol were added to the polymerization reactor, and precondensation was carried out at a stirring speed of 150 rpm and in the presence of a polymerization catalyst. Wherein, the polymerization catalyst is a mixture prepared by titanium isopropoxide and taurine in a mass ratio of 2:1, and the amount of the polymerization catalyst is 0.1% of the total mass of methyl glycolate. The precondensation temperature is 130-190° C., the reaction time is 10 hours, and the precondensation product is obtained. Under the stirring condition of 150 rpm, the polycondensation product is subjected to polycondensation reaction to prepare methyl glycolate copolyester, the polycondensation temperature is 180-235° C., the reaction time is 15 hours, and the vacuum degree is 0.1-100 mmHg. The methyl glycolate copolymer obtained by polycondens...

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Abstract

The invention provides a preparation method of an absorbable poly-methoxycarbonyl glycolate surgical suture. The preparation method comprises the following steps: adopting a methyl glycolate copolymer as the raw material, and then adding polyethylene glycol. The preparation method of the methyl glycolate copolymer is also a key point and comprises the step of enabling reaction of methyl glycolate, adipic acid and butanediol according to a certain proportion in the presence of a catalyst. As the biodegradable methyl glycolate copolymer is adopted to prepare the absorbable surgical suture, biological tests show that the prepared suture has the advantages of mild tissue reaction, small wound healing scar, high strength, excellent knotting performance, high economical efficiency and the like.

Description

technical field [0001] The invention relates to a method for preparing medical materials, in particular to a method for preparing polyglycolic acid methyl ester-based absorbable surgical sutures. Background technique [0002] Absorbable surgical sutures are the development trend of medical surgical sutures today, and have important application prospects. At present, there are mainly catgut, collagen thread, chitosan suture, and biodegradable synthetic polymer suture such as polylactic acid thread. The main requirements of absorbable surgical sutures are small tissue reaction, small wound scar, controllable absorption time, and easy knotting. Sheep catgut is an absorbable suture commonly used in China at present, but there are problems such as high brittleness of the suture, the length of the suture is limited by the length of the sheep intestine, the strength of the catgut is related to the age of the individual animal, and the knotting performance is not ideal. Chinese In...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/06C08G63/16D01F6/84A61L17/12
Inventor 吴晓金翁伟明吴维果毛洪堂
Owner JIANGSU JINJU ALLOY MATERIAL
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