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PDO powder and preparation method thereof

A powder and powder bottle technology, applied in the field of medical cosmetology, can solve the problems of non-degradation, rejection of price, existence of immunity, etc., and achieve the effects of good effect, small tissue reaction, and high strength retention rate

Inactive Publication Date: 2018-10-12
威海威高富森医用材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problems of non-degradable, immunological rejection and high price of dermal fillers at the present stage, and provides a long-lasting, degradable, low-cost, non-toxic and non-repelling PDO powder and its preparation method

Method used

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  • PDO powder and preparation method thereof
  • PDO powder and preparation method thereof
  • PDO powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) dissolving p-dioxanone and L-polylactic acid in hexafluoroisopropanol solvent according to the mass and number ratio of 8:2 to obtain a polymer organic solution;

[0033] (2) The polymer organic solution prepared in step (1) is stirred with the polymer organic solution and polyvinyl alcohol aqueous solution to obtain an emulsion, stirred at a high speed in an emulsion machine, and distilled for 1.5h under 1MPa conditions to prepare get a suspension;

[0034] (3) centrifuging the suspension in step (2), washing and drying with 70% ethanol to obtain PDO microsphere powder, and the particle size of the PDO microsphere powder is 250 microns;

[0035] (4) Wash the powder bottle and stopper with distilled water, dry, put the prepared PDO microsphere powder into the powder bottle, heat-seal the Tyvek paper on the inner wall of the powder bottle by using a special heating tool, sterilize with EO, and dry Finally, the stopper is directly plugged in the mouth of the powder b...

Embodiment 2

[0037] (1) Dissolving p-dioxanone and polycaprolactone in a hexafluoroisopropanol solvent according to the mass and number ratio of 8:4 to obtain a polymer organic solution;

[0038] (2) Stir the polymer organic solution prepared in step (1) with the polyvinyl alcohol aqueous solution to obtain an emulsion, stir at a high speed in an emulsion machine, and distill for 1.25h under the condition of 1.25MPa, Prepare a suspension;

[0039] (3) The suspension in step (2) is centrifuged, washed and dried with 78% ethanol to obtain a PDO microsphere powder, and the particle size of the PDO microsphere powder is 125 microns;

[0040] (4) Wash the powder bottle and stopper with distilled water, dry, put the prepared PDO powder into the powder bottle, place the Tyvek paper horizontally at the mouth of the powder bottle, and its edge should be longer than the mouth of the powder bottle diameter, using a flat heat sealer to heat seal the Tyvek paper on the mouth of the powder bottle, then...

Embodiment 3

[0042](1) Dissolving p-dioxanone and polyglycolic acid in hexafluoroisopropanol solvent according to the mass and number ratio of 8:5 to obtain a polymer organic solution;

[0043] (2) Stir the polymer organic solution prepared in step (1) with the polyvinyl alcohol aqueous solution to obtain an emulsion, stir at a high speed in an emulsion machine, and distill for 1.5h under the condition of 1.5MPa, Prepare a suspension;

[0044] (3) centrifuging the suspension in step (2), washing and drying with 85% ethanol to obtain PDO microsphere powder, and the particle size of the PDO microsphere powder is 5 microns;

[0045] (4) Wash the powder bottle and stopper with distilled water, dry, and put the PDO powder into the powder bottle. The edge of the Tyvek paper should be longer than the diameter of the mouth of the powder bottle. Heat seal on the mouth of the powder bottle, use EO to sterilize, after sterilization, place the powder bottle on a 100-grade clean bench, remove the Tyve...

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Abstract

The invention relates to PDO powder and a preparation method thereof. The problem that at the present stage,dermal fillers cannot be degraded,immunological rejection occurs,and the price is high are solved. The method comprises the following steps that dioxanone and a discrete state material are dissolved into hexafluoroisopropanol solvent at the mass fraction ratio being 8:(2-5),and a polymer organic solution is obtained; the obtained polymer organic solution is stirred and emulsified in an emulsion machine,distillation is conducted at 1 MPa-1.5 MPa,and suspension liquid is obtained; the obtained suspension liquid is subjected to centrifugal separation,70%-85% ethyl alcohol is used for washing,drying is conducted,and the PDO powder is obtained; the obtained PDO powder is loaded into a powder bottle,a special heating tool,a plate heat sealing machine and a 100 class purification table sterilization technology are utilized for conducting sterilization packaging,and a finished product isobtained. The PDO powder and the preparation method thereof are widely applied to the field of medical cosmetology.

Description

technical field [0001] The invention relates to the field of medical cosmetology, in particular to a PDO powder and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the demand for plastic surgery is increasing day by day due to the effect of pursuing beauty and showing beauty. Plastic surgery departments of major hospitals and various medical beauty hospitals are also crowded. With the upgrading of the national economic structure, people's aesthetic concepts are also constantly updated and changed. More people are willing to choose medical cosmetology instead of medical plastic surgery to enhance their charm and image. [0003] There are two main types of cosmetic materials, one is used for tissue lifting, and the other is used for tissue filling. Tissue lifting products are used to solve problems such as facial sagging, and have features such as hooks and claws on the structure, which can position the tissue. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08A61L27/18A61L27/20A61L27/58A61L27/50
CPCC08G63/08A61L27/18A61L27/20A61L27/50A61L27/58A61L2400/06C08L67/04C08L5/08
Inventor 陈晓通于海超薛芮鹏邹美芳刘浩张新硕
Owner 威海威高富森医用材料有限公司
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