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Coating method of antibacterial surgical suture made of high molecular absorbable material

A technique of absorbing materials and surgical sutures, which is applied in the field of preparation of medical surgical sutures for medical devices. It can solve the problems of reduced fiber fracture strength, reduced bending rebound rate, and inflammation of coated tissues, and achieves improved coating utilization and flexibility. Effects of improved smoothness and tight coating adhesion

Active Publication Date: 2012-10-03
SHANDONG HAIDIKE MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most coatings improve the knotting process but reduce the security of the knot, the coating breaks off into the surrounding tissue and may cause tissue inflammation
The spraying method is currently the commonly used coating method due to its simple operation and high efficiency. However, most coating materials are added with toxic and volatile organic solvents such as acetone, chloroform, toluene, xylene, and isopropanol, and the spray is scattered. There are disadvantages such as large loss of coating liquid and poor construction environment
The traditional polyglycolic acid and its polylactide suture thread dyes the fiber during the material polymerization, which reduces the breaking strength of the fiber, and the bending rebound rate of the fiber after dyeing is about 4 to 6 percentage points lower than that before dyeing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] a) Preparation of coating solution

[0026]Put 180g of chitosan with a degree of deacetylation of 70% and 1L of 4% acetic acid aqueous solution into the reaction kettle. hour, make chitosan swell and dissolve, filter, take clear liquid, heat and concentrate again for 0.5 hour, become clear transparent light yellow slurry, make slurry A, then preserve in 30~40 ℃ sealed constant temperature container, standby; 80g of calcium fatty acid, 8g of sorbic acid, 1L of 88% ethanol solution at a temperature of 50-60°C, stirred for 15 minutes, cooled down to 30-40°C, and then added 80g of shikonin, 30g of propyl acetate, inositol Mix hexaphosphoric acid 30m1 to prepare slurry B; prepare slurry B and slurry A at a weight ratio of 1:0.8 and stir for 0.5 hours to fully dissolve and evenly prepare a coating solution. Keep the temperature at 30-40°C for later use.

[0027] b) Impregnation of semi-finished braided sutures

[0028] Soak the braided polymer absorbable surgical sutures in...

Embodiment 2

[0032] a) Preparation of coating solution

[0033] Put 260g of chitosan with a deacetylation degree of 95% and 1L of 6% acetic acid aqueous solution into the reaction kettle, control the temperature in the kettle at 60-80°C, stir for 6 hours, add 150ml of pectin solution with a concentration of 20% and stir for 0.5 hour, make chitosan swell and dissolve, filter, take clear liquid, heat and concentrate again for 0.5 hour, become clear transparent light yellow slurry, make slurry A, then preserve in 30~40 ℃ sealed constant temperature container, standby; 80g of calcium fatty acid, 8g of sorbic acid, 1L of 88% ethanol solution at a temperature of 50-60°C, stirred for 15 minutes, cooled down to 30-40°C, and then added 80g of shikonin, 30g of propyl acetate, inositol Mix hexaphosphoric acid 30m1 to prepare slurry B; prepare slurry B and slurry A according to the weight ratio of 1:1.25 and stir for 0.5 hours to fully dissolve and evenly prepare a coating solution, keep the temperatu...

Embodiment 3

[0039] a) Preparation of coating solution

[0040] Put 220g of chitosan with a deacetylation degree of 85% and 1L of 5% acetic acid aqueous solution into the reaction kettle, control the temperature in the kettle at 60-80°C, stir for 4.5 hours, add 135ml of pectin solution with a concentration of 15% and stir for 0.5 hour, make the chitosan swell and dissolve, filter, take the clear liquid, heat and concentrate for 0.5 hours, and become a clear transparent light yellow slurry, and prepare the slurry A, store it in a sealed constant temperature container at 30-40°C, and set aside; stearin Calcium acid 100g, sorbic acid 10g, 1L of 95% ethanol solution at a temperature of 50-60°C, stirred for 18 minutes, cooled down to 30-40°C, and then added 90g of shikonin, 40g of propyl acetate, inositol six Phosphoric acid 40m1, mix well to prepare slurry B; prepare slurry B and slurry A according to the weight ratio of 1:1 and stir for 0.5 hours, 1 is fully dissolved and uniform, and the coa...

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PUM

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Abstract

The invention discloses a coating method of an antibacterial surgical suture made of a high molecular absorbable material. The method comprises the following steps of: applying a dying process to a coating process; preparing a suture woven by using a warp loom; soaking a primary suture; uniformly spraying a coating liquid onto the suture by adopting a gas-free coating process; and drying and sizing. The suture is reddish violet and fresh in color, is smooth and flexible, is easy for knotting, has high knotting strength, and has the advantages of anti-inflammation, oxidation resistance, high degradability, long tension period and the like; and the safety of a knot is enhanced. The tensile strength is kept by about 70 percent two weeks after clinical suturing; slow absorption starts four weeks later; and the suture is absorbed completely 8-10 weeks later. As proved by clinical application, the antibacterial surgical suture has a wide application range and a good effect, is free from irritability, irritation and inflammatory reactions, and has the advantages of sterilization, anti-inflammation, bacteriostatic action and the like.

Description

technical field [0001] The invention relates to a method for preparing medical surgical sutures, in particular to a coating method for antibacterial surgical sutures made of polymer absorbable materials. Background technique [0002] Surgical sutures made of absorbable polymer materials are the development trend of medical sutures today and have important application prospects. The polymer medical absorbable polyester material represented by polylactic acid (PLA), polyglycolic acid (PGA) and its copolymer polylactide (PLGA) is easy to be absorbed by various microorganisms or animals and plants in nature. Enzyme catabolism, finally forming carbon dioxide and water, has become a hot spot for medical biodegradable materials recently. The application of polyglycolic acid and polylactide is mainly manifested in two aspects of biomedicine and ecology. The application of biomedicine is mainly manifested in medical sutures, drug controlled release carriers, fracture fixation mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/14D06M15/03D06M13/188D06M13/203D06M13/224
Inventor 程光起张建林
Owner SHANDONG HAIDIKE MEDICAL PROD CO LTD
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