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Traditional Chinese medicine composition with high anti-hepatitis C virus activity

A technology of hepatitis C virus and composition, which is applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., and can solve the problems of undiscovered reports of hepatitis C virus in rhubarb saltpeter soup

Active Publication Date: 2017-09-19
SHANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no report about the anti-hepatitis B virus and hepatitis C virus of rhubarb saltpeter soup

Method used

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  • Traditional Chinese medicine composition with high anti-hepatitis C virus activity
  • Traditional Chinese medicine composition with high anti-hepatitis C virus activity
  • Traditional Chinese medicine composition with high anti-hepatitis C virus activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 2700g gardenia, decoct and extract twice, add 32L water each time and decoct for 1 hour, filter the decoction while it is hot, combine the two decoctions, concentrate to 0.5g crude drug / mL, and load the gardenia as per mL of resin 1.5g of crude drug amount is loaded into sample HPD-100 type macroporous resin, washed with water to clarification, and then eluted to colorless with 75% ethanol, the ethanol eluate is collected, dried at low temperature after recovering the solvent, and pulverized into fine powder to obtain 200g gardenia refined components.

[0033] Take 1800g of rhubarb, decoct and extract 3 times, add 18L water to decoct for 0.5h each time, filter the decoction while it is hot, combine the decoction for 3 times, concentrate to 0.75 crude drug g / mL, and load rhubarb as per mL of resin Crude drug amount 0.94g sample AB-8 type macroporous resin, washed to clarification, then eluted to colorless with 95% ethanol, collected ethanol eluate, recovered solvent...

Embodiment 2

[0037] Take 4050g of Gardenia, decoct and extract twice, add 40L water each time and decoct for 1 hour, filter the decoction while it is hot, combine the two decoctions, concentrate to 0.5g crude drug / mL, and load the gardenia per mL of resin The amount of 1.5g of the crude drug is loaded into HPD-100 type macroporous resin, washed with water until clarified, then eluted to colorless with 75% ethanol, collected the ethanol eluate, dried at low temperature after recovering the solvent, and pulverized into fine powder to obtain 300g gardenia refined components.

[0038] Take 2700g rhubarb, decoct and extract twice, add 40L water each time and decoct for 1 hour, filter the decoction while hot, combine the two decoctions, concentrate to 0.75g crude drug / mL, load rhubarb crude drug per mL of resin Load 0.94g of sample AB-8 type macroporous resin, wash with water until clarification, then elute with 95% ethanol until colorless, collect the ethanol eluate, dry at low temperature afte...

Embodiment 3

[0042] Take 675g of Gardenia, decoct and extract 3 times, add 8L of water to decoct for 1 hour each time, filter the decoction while it is hot, combine the 3 decoctions, concentrate to 0.5g crude drug / mL, and load the gardenia per mL of resin The amount of 1.5g of the crude drug is loaded into HPD-100 type macroporous resin, washed with water until clarified, then eluted to colorless with 75% ethanol, collected the ethanol eluate, dried at low temperature after recovering the solvent, and pulverized into fine powder to obtain 52g gardenia refined components.

[0043] Take 450g of rhubarb, decoct and extract twice, add 5L of water each time and decoct for 1 hour, filter the decoction while hot, combine the two decoctions, concentrate to 0.75g crude drug / mL, and load rhubarb crude drug per mL of resin Load 0.94g of sample AB-8 type macroporous resin, wash with water until clarification, then elute with 95% ethanol until colorless, collect the ethanol eluate, dry at low temperatu...

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Abstract

The invention discloses a traditional Chinese medicine composition with high anti-hepatitis c virus activity. The traditional Chinese medicine composition is prepared from the following medicines in parts by weight: 4-15 parts of gardenia, 6-18 parts of rheum officinale and 6-18 parts of cortex phellodendri. The pharmacodynamics study proves that the traditional Chinese medicine composition disclosed by the invention is capable of relatively well inhibiting expression of HepG2 cell line HBeAg and HBsAg antigen, which are stably transfected by HBV genome, plays a certain anti-HBV activity role, is capable of obviously inhibiting expression of Rluc in an HCV-infected (JFH1-luc) report virus Huh7.5.1 cell culture solution and reducing the HCV-RNA content, shows good anti-HCV activity, and is especially significant on inhibition action of hepatitis c virus activity.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for viral hepatitis. The traditional Chinese medicine composition of the invention has activity against hepatitis B virus and hepatitis C virus, especially has more significant activity against hepatitis C virus. Background technique [0002] Hepatitis virus refers to the pathogen that causes viral hepatitis, including hepatitis A, B, C, D, E and other hepatitis viruses. Among them, hepatitis B and C viruses are mostly simultaneously or superimposedly infected with other types of hepatitis viruses, which is one of the main causes of chronic hepatitis, liver cirrhosis and liver cancer. [0003] my country is an area with a high incidence of hepatitis, and hepatitis diseases are on the rise year by year. Viral hepatitis ranks first among all types of hepatitis diseases, among which hepatitis B and C virus infections are the most common. It has the characteristics of high rate and difficu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P31/14A61P1/16A61P31/20
Inventor 裴妙荣孔祥鹏李慧峰
Owner SHANXI UNIV OF CHINESE MEDICINE
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