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A kind of lignan compound containing coumarin structure and its preparation method and application

A technology of lignans and compounds, applied in the fields of active components of heterocyclic compounds, organic chemistry, digestive system, etc., can solve the problems of drug resistance, easy change of skeleton, complex and unique structure of triterpenoids, etc., and achieve good results Effects of anti-hepatitis B virus activity, good anti-neuroinflammatory activity, and good anti-hepatic fibrosis activity

Active Publication Date: 2017-01-04
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the triterpenoids are lanosterane type and cycloaltin type, because their skeletons are easy to change, and the structure of these triterpenoids is complex and unique due to the different degrees of oxidation.
Studies have shown that some nucleosides or their analogue drugs have developed drug resistance in use

Method used

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  • A kind of lignan compound containing coumarin structure and its preparation method and application
  • A kind of lignan compound containing coumarin structure and its preparation method and application
  • A kind of lignan compound containing coumarin structure and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation of compound

[0041] 1. Column conditions:

[0042] 1) Silica gel column: the filler is silica gel with a particle size of 100 mesh;

[0043] 2) MCI column: the filler is polystyrene and divinylphenyl copolymer with a particle size of 100 mesh.

[0044] 2. The preparation of the target compound Coumarinlignan comprises the following specific steps:

[0045]1) Take 20 kg of different-shaped Schisandra chinensis medicinal materials, slice them, and reflux extract with 80% ethanol for 3 times, each time for 2 hours, combine the extracts, concentrate under reduced pressure to obtain alcoholic extract, dissolve in water to obtain a suspension; repeated extraction with petroleum ether for 5 times, and combined the petroleum ether layer extract; repeated extraction with chloroform for 5 times, combined the chloroform layer extract, and concentrated under reduced pressure to obtain the extract;

[0046] 2) Take the extract obtained in step 1), m...

Embodiment 2

[0050] Embodiment 2: the preparation of compound

[0051] The preparation of the target compound Coumarinlignan, compared with Example 1, the preparation method only has the following differences: Step 2) The elution conditions are: successively with petroleum ether-ethyl acetate in volume ratios of 2:1 and 1:1 respectively The mobile phase is used for elution, and the volume of the mobile phase in each ratio is 2 times the column volume. The obtained target compound was 7.8 mg with a purity of 97.6%.

Embodiment 3

[0052] Embodiment 3: the preparation of compound

[0053] For the preparation of the target compound Coumarinlignan, compared with Example 1, the preparation method only has the following differences: Step 2) The elution conditions described are: eluting with petroleum ether-ethyl acetate with a volume ratio of 2:1 as the mobile phase , the volume of the mobile phase is 3 times the column volume. The obtained target compound was 7 mg with a purity of 97.3%.

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Abstract

The invention relates to a lignan compound containing a coumarin structure. The structure of the compound is as follows: the invention also relates to a preparation method of the compound, which includes the following steps: taking the different-shaped Schisandra chinensis as raw material and extracting it with an organic solvent , extraction, elution and separation with a chromatographic column to obtain the compound. The invention also relates to the application of the compound in the preparation of medicines for treating hepatitis B or nervous system diseases.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a lignan compound containing a coumarin structure, and also relates to a preparation method and application of the compound. Background technique [0002] Schisandraceae is a dicotyledonous plant in the family Schisandraceae. There are two genera, Kadsura and Schisandra, with a total of 50 species. They are distributed in East Asia, Southeast Asia and southern North America. Both genera are produced in my country, about 30 species. The remaining species are produced from the southwest to the northeast, but the main producing areas are the southwest and south-central. There are about 25 species of Schisandra, 19 species in my country, distributed from southwest to southeast. [0003] At present, the compounds isolated from Schisandraceae plants mainly fall into two categories: triterpenes and lignans. Most of the triterpenoids are lanosterane and cycloaltin-type, because their ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A61K31/37A61P31/20A61P1/16A61P25/00A61P29/00
Inventor 王炜江星明陈胜璜苏维蔡雄曾嵘胡建
Owner HUNAN UNIV OF CHINESE MEDICINE
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