Traditional Chinese medicinal preparation for treating acute and chronic orchitis and preparation process of traditional Chinese medicinal preparation

A technique of traditional Chinese medicine preparation, orchitis, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2015-06-24
王雪雁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 2. Plague Bet

Method used

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  • Traditional Chinese medicinal preparation for treating acute and chronic orchitis and preparation process of traditional Chinese medicinal preparation
  • Traditional Chinese medicinal preparation for treating acute and chronic orchitis and preparation process of traditional Chinese medicinal preparation
  • Traditional Chinese medicinal preparation for treating acute and chronic orchitis and preparation process of traditional Chinese medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050]In order to verify the feasibility of the proportioning range of the Chinese medicine prescription of the present invention, select representative 5 groups of weight proportions for the actual production of granules, and the production process executes the optimal process parameters of the preparation process of the present invention, these 5 groups The proportions are respectively numbered as groups A, B, C, D, and E, wherein the two groups of A and B are two optimal prescription proportions, and the groups C, D, and E are respectively the maximum weight ranges of the traditional Chinese medicine prescriptions of the present invention. , minimum, and arbitrary values. The raw material ratio of each group is as shown in Table 1:

[0051] Table 1 Raw material ratio of each group

[0052]

[0053] (1) Accurately weigh Citrus aurantium, betel nut, psoralen, dried ginger, white peony, peach kernel, achyranthes bidentata, gentian, rehmannia glutinosa, mirabilite, winter m...

Embodiment 2

[0058] The toxicity test of the manufactured granule of embodiment 1

[0059] (1) Acute toxicity test

[0060] 1. Drug under test: 5 kinds of granules manufactured in Example 1 of the present invention, added purified water and modulated into a thin paste for subsequent use.

[0061] 2. Experimental animals: Kunming mice, weighing 21g±2g, male and female, and all female mice are sterile. Purchased from the Department of Laboratory Animal Science, School of Medicine, Fudan University.

[0062] 3. Gavage 5 kinds of traditional Chinese medicine dilute pastes to the mice in the 5 groups. When the doses of 554.7, 568.2, 511.6, 593.4, and 575.3 g crude drugs / kg were respectively administered, the mice showed a slight decrease in activity after administration, 1 The situation returned to normal in about 1 hour. After administration, the animals were observed continuously for 7 days. No animal died in each group, and its general condition, diet, water intake, urine and weight gain w...

Embodiment 3

[0082] Pharmacodynamic experiment of Chinese medicine preparation of the present invention

[0083] 1. Inhibition of PGE2 synthesis in rat inflammatory tissue:

[0084] Get about 50 rats of 180 ± 10g, male or female, and divide them into 5 groups at random. The traditional Chinese medicine granules of the present invention have high, medium and low doses (8, 4, and 2 times the clinical daily dose), amoxicillin and clavulanate potassium (referred to as Ake) control group and blank control group, 10 rats in each group. Dosage: 5.44, 2.72, and 1.36 g crude drug / kg for the high, medium, and low levels of this product; 0.00625 g / kg for the Ake group; three days of continuous administration, 1 hour after the last drug, 1% carrageenan was subcutaneously injected into the right hind foot Vegetable glue 0.1ml, 4 hours after inflammation, the rats were killed, the swollen feet were cut off at 0.5cm above the ankle joint, peeled, cut into pieces, soaked in 5ml of normal saline for 1 hou...

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Abstract

The invention discloses a traditional Chinese medicinal preparation for treating acute and chronic orchitis and a preparation process of the traditional Chinese medicinal preparation, and belongs to the field of traditional Chinese medicine. Eighteen traditional Chinese medicinal materials including immature bitter oranges, betel nuts, fructus psoraleae, rhizoma zingiberis, white paeony roots, peach kernels, the roots of bidentate achyranthes, felwort, prepared rehmannia roots, mirabilite, seeds of Chinese wax gourds, rheum officinale, Chinese angelica, red flowers, piper cubeba, scutellaria baicalensis, rhizoma alismatis and liquorice can be produced into the traditional Chinese medicinal preparation according to the preparation process. The traditional Chinese medicinal preparation has the curative advantages of good effect, recuperative medical care, easiness in radical cure, difficulty in relapse and the like in terms of treatment of the acute and chronic orchitis, and has the technical advantages such as high stable efficacy of a finished preparation, simple preparation process and equipment and applicability to mass production, popularization and application.

Description

technical field [0001] The invention discloses a traditional Chinese medicine preparation for treating acute and chronic orchitis and a preparation process thereof, belonging to the field of traditional Chinese medicine. technical background [0002] Orchitis belongs to the category of "zi carbuncle" in traditional Chinese medicine. Traditional Chinese medicine believes that the main etiology and pathogenesis of this disease is due to liver and kidney yin deficiency or yangming blazing heat. From, it is caused by going against the inside of the flesh; or it is caused by damp-heat injection, and it is knotted in the kidney to feel the evil from the outside, and it follows the meridians and collaterals, and forms a carbuncle; or due to trauma, blood stasis stagnates in the sub-system, accumulating heat and producing pus; or caused by trauma. Unclean intercourse, external infection of turbid toxin, invasion of the Fu system, stagnation into fire and pus. Therefore, red, swolle...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P15/00A61K33/04
Inventor石洪光
Owner王雪雁