Uses of FTY720 in preparation of xerophthalmia treating drugs

A 1. FTY720, dry eye technology, used in drug combinations, sensory diseases, etc., can solve problems such as no research reports on FTY720 dry eye.

Inactive Publication Date: 2015-07-15
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been no research reports on the use of FTY720 in the treatment of dry eye at home and abroad

Method used

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  • Uses of FTY720 in preparation of xerophthalmia treating drugs
  • Uses of FTY720 in preparation of xerophthalmia treating drugs
  • Uses of FTY720 in preparation of xerophthalmia treating drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0022] 1. Experimental animals: 168 10-week-old male NOD mice were purchased from the Jiuting Experimental Animal Center of the Shanghai Branch of the Chinese Academy of Sciences, and the animal room of the Health Science Research Center of the Shanghai Academy of Biological Sciences, the Chinese Academy of Sciences was uniformly cleaned and raised. The Sjogren syndrome model of the mice is foreign It has been confirmed by relevant research.

[0023] 2: Drug source: FTY720 is pure white crystal, donated by Mr. Ma Qiming of Zhejiang Hangzhou Tongming Technology Co., Ltd., dissolved in normal saline into an aqueous solution (the pH value of the concentration used in this application after dilution with normal saline is between 7.28 and 7.52 , the same below), CsA eye drops were purchased from the Eye, Ear, Nose and Throat Hospital Affiliated to Fudan University, and normal saline was further diluted into an aqueous solution.

[0024] Experimental reagents: phenol red cotton thre...

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PUM

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Abstract

The present invention belongs to the field of drug applications, and relates to new uses of FTY720 in pharmacy, particularly to uses of the FTY720 in preparation of xerophthalmia treating drugs, especially to new uses of the FTY720 in preparation of an ocular surface disease Sjogren syndrome drugs, wherein the FTY720 provides immunoregulation and inhibition effects for ocular surface autoimmunity inflammations adopting the Sjogren syndrome as the representative. According to the present invention, animal experiment results demonstrate that: after the diluted FTY720 is administered to the mouse ocular part in an ocular drop manner, the inflammation symptoms of the Sjogren syndrome of the treated NOS mouse are significantly relieved, the mass and the quality of tears are significantly improved, the tear film breaking time is significantly prolonged, and the proinflammatory factor level and the MMP level in the tear and the ocular surface tissue are significantly reduced. Further the FTY720 can be prepared into the drug for treating the ocular surface disease adopting the Sjogren syndrome as the representative, and is especially prepared into the ocular drop with the specific use concentration range.

Description

technical field [0001] The invention belongs to the field of pharmaceutical applications, and relates to the new application of FTY720 in pharmacy, in particular to the application of FTY720 in the preparation of drugs for the treatment of dry eye, especially in the preparation of drugs for the treatment of ocular surface diseases New uses in syndrome drugs, the FTY720 to The ocular surface autoimmune inflammation represented by the syndrome has immunomodulatory and inhibitory effects. Background technique [0002] Studies have reported that dry eye syndrome is one of the major ocular surface diseases, which refers to tear abnormalities and ocular surface inflammation caused by multiple factors. tissue damage. During the pathogenesis, the tear film osmolarity and ocular surface inflammation are combined (Lemp, M.A. 2007. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61P27/02
Inventor 叶纹肖位保
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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