Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of tipranavir to breast cancer-resistant drug and breast cancer-resistant drug

A tipranavir, anti-breast cancer technology, applied in the field of medicine to achieve the effect of strong affinity and delaying speed

Inactive Publication Date: 2015-07-22
CHONGQING UNIV OF TECH +1
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tipranavir has only been used as a drug for the treatment of AIDS for many years, and no relevant research has proved that it has anti-cancer and anti-tumor activity, especially no related research has proved that tipranavir has anti-mammary gland function targeting SIRT1. Cancer efficacy, so there is no anticancer drug targeting SIRT1

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of tipranavir to breast cancer-resistant drug and breast cancer-resistant drug
  • Application of tipranavir to breast cancer-resistant drug and breast cancer-resistant drug
  • Application of tipranavir to breast cancer-resistant drug and breast cancer-resistant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] The present invention will be described in further detail below in conjunction with accompanying drawing and specific embodiment, and the raw material used in the embodiment is common commercially available unless otherwise specified.

[0037] 1. Virtual Screening

[0038] Using the suflex-docking module in SYBYL2.0 to analyze the active site of Tipranavir (A1, the binding site of the endogenous inhibitor nicotinamide) ( figure 1 with image 3 ) and active site two (A2, the binding site of the exogenous inhibitor EX527) ( figure 2 with Figure 4 ) combination mode and amino acid residues.

[0039] For active site one and two ( Figure 5 ) after virtual screening, the top 100 molecules with the highest docking scores were obtained (deleting 24 identical molecules with different conformations), the results are shown in Table 1, and 932 is the screened SIRT1 inhibitor Tipranavir.

[0040] Table 1 Virtual screening results

[0041]

[0042]

[0043]

[0044]...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses application of tipranavir to a breast cancer-resistant drug and the breast cancer-resistant drug. The tipranavir is used for preparing the breast cancer-resistant drug. The invention provides the breast cancer-resistant drug comprising the tipranavir. The tipranavir serves as a main active component for resisting the breast cancer. By using a computer virtual screening method, a molecule namely the tipranavir is selected, and the matching degree between the tipranavir and an SIRT1 active pocket is highest; the proliferation inhibition rate of breast cancer cells further reaches 82.10 percent after the cancer is treated by the tipranavir for 72 hours through the verification of a cell experiment; a flow cell experiment result shows that the tipranavir has an apoptosis-inducing effect on the breast cancer cells; an experiment result shows that the tipranavir can remarkably inhibit the activity of breast cancer tumor cells and has a broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the application of Tipranavir (Tipranavir), in particular to the application of Tipranavir in anti-breast cancer drugs and the anti-breast cancer drugs. Background technique [0002] Cancer, namely malignant tumor, is a major disease that seriously endangers human life. The treatment of cancer has received widespread attention from society. Breast cancer is the most common cancer among women in China, as in most other countries. Every year, the number of new cases and deaths of breast cancer in China account for 12.2% and 9.6% of the world's respectively. Since the 1990s, the incidence of breast cancer in China has grown at more than twice the global rate, especially in urban areas. Currently, breast cancer is the most common cancer among Chinese women. Chemotherapy is one of the three basic means of breast cancer treatment. Although many advances have been made in breast cance...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4433A61P35/00A61K31/427
CPCA61K9/2059A61K31/427A61K31/4433A61K2300/00
Inventor 林治华王锐郭波舒茂王远强胡勇孟令鑫
Owner CHONGQING UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com