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Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof

A technology for sustained-release injections and chicken coccidiosis, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc. It can solve the problems of difficult storage, instability, unsafe prevention and treatment effects, etc., and achieve the inhibition of Mycobacterium tuberculosis Effect

Inactive Publication Date: 2009-07-15
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from the above that most of the current anti-coccidiosis Chinese herbal medicines, whether they are decoctions or powders, are administered orally. Animals cannot obtain the therapeutic dose that should be achieved through oral administration, and as a result, the control effect is greatly affected
At the same time, although it is generally believed that Chinese herbal anticoccidial drugs are relatively safe, there are still reports that some anticoccidial Chinese herbal medicines, like chemical anticoccidial drugs, have some inhibitory effects on the growth of animals after taking them. Therefore, the current anticoccidial Chinese herbal medicines In the application of production, there are still problems such as large dosage, difficult storage, unsafe and unstable prevention and treatment effect, not significant, and high cost, which urgently need to be studied and solved

Method used

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  • Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof
  • Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof
  • Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: (preparation method 1 of Chinese herbal medicine anticoccidial sustained-release injection)

[0038] (1) Various commercially available raw materials were dried in a blast oven at 45 to 50°C for more than 4 hours, and were pulverized into fine powders with a traditional Chinese medicine pulverizer respectively. Weighed 50 g of pulverized raw materials Annua Artemisia annua, 50 g of Sophora flavescens, Pulsatilla 37.5g, Agrimony 37.5g, Bupleurum 25g, mixed, set aside;

[0039] (2) Soak the drug mixture in step (1) with 95% ethanol (about 400ml). The amount of ethanol should be about 1cm above the drug surface. The container should be sealed to prevent the ethanol from volatilizing. Once, after 48 hours, centrifuge the extract, soak the residue with 95% ethanol, the amount of ethanol should be about 1cm above the drug surface, seal the container, stir 1-2 times a day during the soaking process, and after 48 hours, Centrifuge the extract, and combine it with...

Embodiment 2

[0044] Embodiment 2: (preparation method 2 of Chinese herbal medicine anticoccidial sustained-release injection)

[0045] (1) Dry the commercially available raw materials in a blast oven at 45-50°C for more than 4 hours, grind them into fine powders with a traditional Chinese medicine grinder, and weigh 50 g of powdered Artemisia annua, 50 g of Sophora flavescens, and 37.5 g of Agrimony. g. Pulsatilla 37.5g, Bupleurum 25g, pomegranate peel 37.5g, Phellodendron 25g, Burnet 25g, Qinpi 25g, Angelica 25g, Radix Paeoniae Alba 12.5g, Licorice 12.5g, mixed and set aside;

[0046] (2) Soak the drug mixture in step (1) with 95% ethanol. The amount of ethanol should be about 2cm above the surface of the drug, and the container should be sealed to prevent the volatilization of ethanol. During the soaking process, stir 1-2 times a day for 72 hours Finally, centrifuge the extract, soak the residue with 95% ethanol, the amount of ethanol should be about 2cm above the drug surface, seal the ...

Embodiment 3

[0051] Embodiment 3: (preparation method 3 of Chinese herbal medicine anticoccidial sustained-release injection)

[0052] The processing technology of this example is the same as that of Example 1; and the ethanol extract A1 and water extract A2 prepared in Example 1 are used.

[0053] (1) Dry the commercially available raw materials in a blast oven at 45-50°C for more than 4 hours, pulverize them into fine powders with a traditional Chinese medicine pulverizer respectively, and weigh 37.5 g of powdered pomegranate peel, 25 g of Cortex Phellodendri, and 25 g of Burnet , Qinpi 25g, Angelica 25g, Paeoniae Alba 12.5g, Licorice 12.5g, mixed and set aside;

[0054] (2) Process the drug mixture in step (1) into ethanol extract C1 and water extract C2;

[0055] (3) Remove the tannins in the ethanol extract C1 and the water extract C2 respectively by the alternating heat and cold method, centrifuge, and the supernatant is for subsequent use;

[0056] (4) Weigh 50 g of β-cyclodextrin...

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Abstract

The invention discloses a slow-release injection of Chinese herbal medicine for preventing and treating coccidiosis in rabbits and chickens and a preparation method thereof, belonging to the technical field of drug prevention and control of livestock and poultry parasites. The composition and weight content of the slow-release injection are: 3-6 parts each of Artemisia annua and Sophora flavescens, 2-5 parts each of Pulsatilla, Agrimony and Bupleurum, 2-4 parts of inclusion agent β-cyclodextrin; After twice leaching with 95% ethanol, the ethanol extract A1 was made, and the residue was extracted twice with water to make the water extract A2; the tannins in A1 and A2 were removed by alternating heat and cold; and then mixed with β -Cyclodextrin inclusion, finally made into sustained-release injection containing 1.0g of raw material crude drug per milliliter of liquid medicine. The drug is not taken orally, and the dosage is accurate. Each sick rabbit or chicken is injected with 2ml, which can greatly reduce the dosage of the drug, is easy to absorb, and has a rapid effect. It has no toxic and side effects, and delays the generation of coccidian drug resistance, maintains the sensitivity of some anticoccidial drugs, and further delays the generation of coccidian drug resistance. The drug can be used for the prevention and treatment of coccidiosis in rabbit and chicken production.

Description

technical field [0001] The invention relates to the technical field of drug prevention and control of livestock and poultry parasites, in particular to a Chinese herbal medicine slow-release injection for preventing and treating coccidiosis in rabbits and chickens and a preparation method thereof. Background technique [0002] Coccidiosis is the most serious parasitic disease to rabbit industry and chicken industry. The fatality rate of coccidiosis to rabbits can reach 40-80%, and the cost of anticoccidial drugs in my country is as high as billions of yuan every year. [0003] Up to now, the main means of controlling coccidiosis still relies on the chemical control of coccidiostats. Due to the long-term use of anticoccidial drugs, such as diclazuril and cloxyridine, drug resistance of coccidiostats has become an unavoidable serious problem. Finally, it will cause drug resistance of coccidia. [0004] As coccidia drug-resistant strains are increasing, the control effect of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/756A61K9/10A61P33/02
Inventor 卢福庄张雪娟方兰勇付媛冯尚连程菊芬周永学陈学智
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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