Application of traditional Chinese medicine composition in preparation of medicines for treating atherosclerosis

A technology of atherosclerosis and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of drugs for treating atherosclerosis, can solve the problems of no preventive measures and therapeutic drugs, and the etiology and pathogenesis have not yet been fully elucidated, achieving The effect of highlighting substantive features

Inactive Publication Date: 2015-07-22
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicines for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Take 18g of Digeria chinensis, 20g of Datian Jihuang, 15g of Bamboo Lingxiao, 18g of velvet duck foot wood, 20g of Shijiao grass, 12g of Pennisetum 12g, and 20g of wild jute, add water to decoct 2 times, add The amount of water is 10 times of the weight of the medicinal materials, decocted for 2 hours, the second time of adding water is 8 times of the weight of the medicinal materials, decocted for 1 hour, combined the decoction, concentrated, dried, and pulverized to obtain the traditional Chinese medicine composition granules. The concentration conditions are: : 0.07MPa, concentrated under reduced pressure at 60-70°C to 65°C, the relative density is 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0017] Example 2: Pharmacological study of Chinese medicine composition on atherosclerosis

[0018] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0019] 2. Materials and methods: Experimental animals: healthy rats, half male and half male, body weight (200.0±20) g. Feed: Basic feed was provided by Jiangsu Experimental Animal Center; high-fat feed consisted of 2% cholesterol, 10% lard and 88% basic feed, processed by Jiangsu Experimental Animal Center. Equipment: Abbott AEROSET automatic biochemical analyzer; JY601 electronic balance: Shanghai Haikang Electronic Instrument Factory; TN-100B tray torque balance: Shanghai Shangping Instrument Company; OLYMPUS inverted system microscope; WF10X-18MM optical microscope: Chongqing Optical Instrument factory; TGL-16G centrifuge: Shanghai Anting Technology Instrument Factory

[0020] 3. Experimental method:

[0021] 3.1 Animals were fed with basal feed for 1w as an adaptation period. Randomly divi...

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Abstract

The invention relates to an application of a traditional Chinese medicine composition in preparation of medicines for treating atherosclerosis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 18 parts of hypericum japonicum, 20 parts of lysimachia fortunei maxim, 15 parts of disporum sessile, 18 parts of schefflera delavayi harms, 20 parts of chinarue, 12 parts of Chinese pennisetum and 20 parts of wild jute. The traditional Chinese medicine composition can play a role in resisting atherosclerosis by adjusting blood fat and protecting endothelial cells, and has remarkable progress.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of drugs for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. Contents of the invention [0003] The invention provides an application of a traditional Chinese medicine composition in the preparation of anti-atherosclerosis drugs. [0004] An application of a traditional Chinese medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P9/10
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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