Extraction method and application of anti-tumor traditional Chinese medicine extract

An extraction method and extract technology are applied in the field of anti-tumor traditional Chinese medicine extracts and their extraction, which can solve the problems of high cost and large body damage, and achieve the effects of low cost, reduced expression amount and wide source of raw materials.

Active Publication Date: 2015-07-29
SHAANXI UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And traditional tumor (malignant tumor) treatment adopts means such as western medicine, radiotherapy, chemotherapy or operatio

Method used

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  • Extraction method and application of anti-tumor traditional Chinese medicine extract
  • Extraction method and application of anti-tumor traditional Chinese medicine extract
  • Extraction method and application of anti-tumor traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Using the dried rhizome of Hylomecon japonica (Thunb.) pratl as raw material, reflux extraction with ethanol with a volume concentration of 70% and a mass 20 times that of the raw material, to obtain the first extract and the first extracted medicinal residue; Adding ethanol with a volume concentration of 70% and a mass 18 times that of the raw material to the first extracted dregs is used for secondary extraction to obtain a second extract and a second extracted dregs; in the second extracted dregs Adding ethanol with a volume concentration of 70% and a quality 18 times that of the raw material is extracted for the third time to obtain a third extract and a third extract of medicinal residues; the first extract, the second extract, and The third extracts are combined to obtain an extract; the extracts are concentrated to obtain a thick ointment; the thick ointment is dried at 70° C. and then pulverized to obtain an anti-tumor traditional Chinese medicine extract.

Embodiment 2

[0060] Using the dried rhizome of H.japonica (Thunb.) pratl.Var.dissecta (Franch savat.) Fedde as raw material, reflux extraction with ethanol with a volume concentration of 60% and a mass 19 times that of the raw material, to obtain The first extraction liquid and the first extraction dregs; adding ethanol with a volume concentration of 60% and a mass 17 times that of the raw material in the first extraction dregs for secondary extraction to obtain the second extraction liquid and the second extraction dregs. Extracting medicinal residues; adding ethanol with a volume concentration of 70% and a mass 17 times that of the raw material to the second extracted medicinal residues for a third extraction to obtain a third extract and a third extracted medicinal residues; The first extract, the second extract and the third extract are combined to obtain an extract; the extract is concentrated to obtain a thick paste; the thick paste is dried at 65°C and crushed to obtain Antitumor tr...

Embodiment 3

[0062] With the dry rhizome of H.japonica (Thunb.) pratl.Var.Subincia Fedde as raw material, the volume concentration is 80%, and the quality is 21 times of the ethanol reflux extraction of the raw material to obtain the first extract and The first extraction of medicinal residues; adding ethanol with a volume concentration of 80% and a mass 19 times that of the raw material to the first extraction medicinal residues for secondary extraction to obtain a second extraction liquid and second extraction medicinal residues; Adding ethanol with a volume concentration of 80% and a mass 18 times that of the raw material to the second extracted dregs is added for a third extraction to obtain a third extract and a third extracted dregs; the first extract , the second extract and the third extract are combined to obtain an extract; the extract is concentrated to obtain a thick paste; the thick paste is dried at 70°C and crushed to obtain an anti-tumor traditional Chinese medicine extract ...

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Abstract

The invention provides an extraction method and an application of an anti-tumor traditional Chinese medicine extract, and belongs to the field of traditional Chinese medicines. The extraction method of the anti-tumor traditional Chinese medicine extract comprises the steps that alcohol reflux extraction is performed by taking roots and stems of papaveraceae and hylomecon plants as raw materials; an obtained extraction solution is condensed and dried; and the anti-tumor traditional Chinese medicine extract is obtained. The anti-tumor traditional Chinese medicine extract can increase percentages of G1-phase cells of HT-29 and SW620 cells, can reduce a ratio of S-phase cells to G2-phase cells of the tumor cells, and has effects of inducing the HT-29 and SW620 cells to generate G1-phase retardarce and inhibiting the multiplication capacity of the two tumor cells; and in addition, after a colon cancer cell is treated by the anti-tumor traditional Chinese medicine extract, the expression quantity of caspase-3 and caspase-9 which are formed via activation can be increased, the expression quantity of protein for promoting apoptosis of the cells can be increased, and the expression quantity of protein for inhibiting the apoptosis of the cells can be reduced.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an anti-tumor traditional Chinese medicine extract and its extraction method and application. Background technique [0002] my country has a vast territory, diverse natural conditions, and extremely rich traditional medicine resources. It is the country with the most types of natural medicine resources and the longest cultivation history in the world. And many authentic medicinal materials are well-known at home and abroad, and exported to more than 100 countries and regions. [0003] Chinese herbal medicine has unique advantages that are incomparable to western medicine, such as natural materials, stable effects, and less toxic and side effects. With the progress of society and the development of productivity, people are increasingly pursuing health and longevity. Modern people are increasingly turning their attention from synthetic medicine to natural medicine. It i...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P35/00
Inventor 孙静张欣孙阳唐志书郭东艳
Owner SHAANXI UNIV OF CHINESE MEDICINE
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