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Application of decoy receptor 3 in the treatment of sepsis

A decoy receptor, sepsis technology, applied in the application field of decoy receptor 3 in the treatment of sepsis drugs, can solve the problems of different therapeutic effects, poor repeatability, unstable effects, etc., and achieve inhibition of lymphocyte apoptosis. death, protect function, reduce the effect of inflammatory response

Inactive Publication Date: 2018-09-07
上海市松江区中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above strategies have achieved certain curative effects, such as being able to inhibit the inflammatory response and improve the survival rate, etc., there are also problems of unstable effects and poor repeatability of experiments.
It is manifested that the same treatment plan can have different therapeutic effects at different times and different individuals, or the same treatment plan can achieve ideal curative effect in the laboratory, but the effect is poor in clinical trials, etc.

Method used

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  • Application of decoy receptor 3 in the treatment of sepsis
  • Application of decoy receptor 3 in the treatment of sepsis
  • Application of decoy receptor 3 in the treatment of sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This experiment uses a sepsis mouse model to study in vitro whether DcR3 has a protective effect on mouse sepsis, and to study whether DcR3 affects lymphocyte apoptosis and function through in vitro cell stimulation experiments, and to explore its role in sepsis. role in the immune regulation of sepsis, and a plausible therapeutic target for sepsis immunotherapy.

[0030] experimental method

[0031] 1. Establishment of CLP-induced sepsis mouse model

[0032] Male BALB / c mice (body weight 25-30 g) aged 8-10 weeks were fasted for 8 hours before operation and allowed to drink water freely. Anesthesia was performed by intraperitoneal injection of 2% chloral hydrate solution before operation. The mice were placed supine on the operating table, their limbs and head were fixed, the hair on the lower abdomen was shaved and routine disinfection was performed. Make a longitudinal skin incision in the middle of the lower abdomen (about 1.5 to 2 cm in length), identify the line...

Embodiment 2

[0052] This experiment uses a sepsis mouse model to study in vitro whether DcR3 has a protective effect on mouse sepsis, and to study whether DcR3 affects lymphocyte apoptosis and function through in vitro cell stimulation experiments, and to explore its role in sepsis. role in the immune regulation of sepsis, and a plausible therapeutic target for sepsis immunotherapy.

[0053] experimental method

[0054] 1. Establishment of CLP-induced sepsis mouse model

[0055] Male BALB / c mice (weight 25-30 g) aged 8-10 weeks were fasted for 8 hours before the operation and allowed to drink water freely. Anesthesia was performed by intraperitoneal injection of 2% chloral hydrate solution before operation. The mice were placed supine on the operating table, their limbs and head were fixed, the hair on the lower abdomen was shaved and routine disinfection was performed. Make a longitudinal skin incision in the middle of the lower abdomen (about 1.5 to 2 cm in length), identify the linea...

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Abstract

The invention relates to an application of a decoy receptor 3 in preparation of medicine for treating sepsis, which is characterized in that expression of DcR3 in serum of sepsis patients is increased, and DcR3 is relative to mortality of sepsis, DcR3 is participate to generation and development of sepsis, and can reduce the mortality of sepsis mice, reduce inflammation reaction of sepsis mice, inhibit lymphocytic apoptosis of sepsis mice, protect organs such as liver and lung; so that DcR3 has certain treatment effect for sepsis.

Description

technical field [0001] The invention belongs to the technical field of new application of drugs, and relates to the application of decoy receptor 3 in drugs for treating sepsis. Background technique [0002] Septicemia (sepsis) is a type of a variety of pathogenic bacteria that enter the blood system of the body and multiply rapidly, producing a large amount of toxins, and the body is stimulated to produce an excessive inflammatory response. At present, sepsis is still the number one cause of death in ICU patients, and the mortality rate is on the rise. According to statistics, in western developed countries, about 1.5 million people get sick every year, and the mortality rate is as high as 30%-50%. In terms of the pathogenesis of sepsis, although great progress has been made in recent years, it has not yet been fully elucidated, which also hinders the effective treatment of sepsis and leads to high mortality. Regarding the pathogenesis of sepsis, there are currently two v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P31/04
Inventor 侯彦强梁冬雨
Owner 上海市松江区中心医院
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