Uses of organic-inorganic hybrid polyanoxometalate compounds

Abstract

The invention discloses new uses of organic-inorganic hybrid polyanion oxometalate compounds Na3[AlMo6(OH)6O18]}(H2D-Thr)2 and Na3[AlMo6(OH)6O18]}(H2D-Arg)2, It is the organic-inorganic hybrid polyoxometalate compounds Na3[AlMo6(OH)6O18]}(H2D-Thr)2 and Na3[AlMo6(OH)6O18]}(H2D-Arg)2 in the preparation of antivenoms application in medicine. The organic-inorganic hybrid polyanion oxometalate compound Na3[AlMo6(OH)6O18]}(H2D-Arg)2 described in the present invention, the experimental results show that the amino acid-modified Anderson-type polyanion can not only neutralize snake venom but also further Reducing the pain of snake venom bites in mice (reducing discomfort symptoms such as twitching and licking the injured part) provides a new idea for the research and development of antivenom preparations, which has important scientific significance and broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the new application of organic-inorganic hybrid polyanoxometalate compounds. Background technique [0002] Snake venom is a liquid secreted by poisonous snakes from the venom glands. The main component is toxic protein, which accounts for about 90% to 95% of the dry weight. There are more than 20 kinds of enzymes and toxins. In addition, it also contains some small molecular peptides, amino acids, carbohydrates, lipids, nucleosides, biogenic amines and metal ions. The composition of snake venom is very complex, and the toxicity, pharmacology and toxicological effects of different snake venoms have their own characteristics. [0003] Venomous snake bites have the characteristics of acute onset, rapid changes, many complications, complicated treatment, disability, and high fatality rate. If the treatment is not timely or inappropriate, it often leads to adverse cons...

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Problems solved by technology

[0004] A venomous snake bite can seriously aggravate the injury and lead to a greatly increased mortality rate if left untreated

Although antivenom can effectively neutralize the corresponding snake venom, there are many problems in practical application: first, the specificity of the venom is strong, the snake species must be identified before medication, and the best curative effect can be achieved by medication immediately after the bite. Because it is expensive and difficult to store for a long time, it is not easy to get available antivenom in time even in developed areas, and it is even more difficult in mountainous areas with inconvenient transportation; in addition, antivenom is prone to allergies, some clinicians emphasize Do not use antivenom as a routine drug for snakebite, but only use it when there are obvious symptoms of systemic poisoning

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