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Application of tuccinic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency

A technology for Alzheimer's disease and estrogen deficiency, applied in drug combinations, sexual diseases, pharmaceutical formulations, etc., can solve problems such as controversy, increase breast cancer risk, increase irregular vaginal bleeding, etc., to increase the number, improve Effects of Cognitive Dysfunction

Active Publication Date: 2020-05-08
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Estrogen replacement therapy has been affirmed, but it is still controversial as a safe long-term drug, such as increasing irregular vaginal bleeding and increasing the risk of breast cancer, etc.

Method used

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  • Application of tuccinic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency
  • Application of tuccinic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency
  • Application of tuccinic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency

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Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1 Materials and methods

[0019] 1.1 Modeling and grouping

[0020] Modeling of ovariectomized dementia model mice: C57BL mice, 3 months old and weighing (30±2) g, were selected. The mice were anesthetized intraperitoneally with pentobarbital sodium (0.25mL / 100g) at a mass concentration of 1.5%, and the skin above the pubic bone was disinfected, and the skin above the pubic bone was incised 2 cm along the midline, and the abdominal wall muscle layer was cut and the abdominal cavity was opened. The bilateral pink ovaries were separated and exposed, the bilateral ovaries were ligated and removed (ovariectomy, OVX), the muscles and skin were sutured in turn, and postoperative iodine disinfection was performed. In the sham group, only the ovaries were exposed. The vaginal cell smear was performed on the 3rd day after the operation, and the appearance of epithelial keratinocytes for 7 consecutive days proved that the ovariectomy was successful. The ovariectomy dementia mo...

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Abstract

The invention discloses an application of tulmanic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency, and belongs to the technical field of new medical applications of tulmanic acid. The main points of the technical scheme of the present invention are: the application of tuccinic acid in the preparation of drugs for the treatment or prevention of Alzheimer's disease caused by estrogen deficiency, wherein the molecular formula of tuccinic acid is C 30 h 48 o 5 , the structural formula is: . Tomanic acid of the present invention can improve the cognitive dysfunction of AD patients, increase the number of cholinergic neurons in the brain, and has neuroprotective effect on CNS, which may be realized by ERα. The choice of drugs for postmenopausal women with AD provides an experimental basis.

Description

technical field [0001] The invention belongs to the technical field of new medical applications of tuccinic acid, and specifically relates to the application of tuccinic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is a common degenerative disease of the nervous system, manifested as the deposition of senile plaques, progressive learning and memory loss and mental decline. The main component of senile plaques is β-amyloid polypeptide (beta-amyloid, Aβ). Studies have reported that the reduction of estrogen levels in the blood of female patients is closely related to the clinical symptoms of AD. Estrogen not only regulates reproduction and body development, but also reduces excitatory amino acid release, neuroprotection and improves learning and memory. Epidemiology shows that AD is a gender-prone disease, and the incidence rate of eld...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P25/28A61P5/30A61P15/00
Inventor 崔卫刚张应花王松涛孙春莉连辉
Owner XINXIANG MEDICAL UNIV
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