LC Oscillator Magnetic Sensitive Biosensor Based on Switched Capacitor In Situ Self-Calibration Technology

A technology of switched capacitors and oscillators, applied in the field of biosensors, can solve the problems of increasing the cost and complexity of sensor chips, limiting mass production applications, etc., achieving layout and wiring and timing control optimization, and improving design reliability and robustness , The effect of improving the detection sensitivity

Inactive Publication Date: 2017-10-03
TSINGHUA UNIV
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Problems solved by technology

However, this type of method not only requires an additional doubling of the on-chip area to be used as a reference area, but also requires an off-chip microfluidic device to control the flow of liquid only to the detection area, which greatly increases the cost and complexity of sensor chip implementation and limits Its mass production application

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  • LC Oscillator Magnetic Sensitive Biosensor Based on Switched Capacitor In Situ Self-Calibration Technology
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  • LC Oscillator Magnetic Sensitive Biosensor Based on Switched Capacitor In Situ Self-Calibration Technology

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[0017] In order to make the object, technical solution and features of the present invention clearer, specific implementation methods will be described in detail below in conjunction with the accompanying drawings.

[0018] The present invention proposes an LC oscillator magnetosensitive biosensor based on the in-situ self-calibration technology of on-chip switched capacitors. The on-chip LC oscillator is used as a detection module, and the change of the output frequency is detected by the change of the inductance caused by the magnetic particles. The sensor composed as figure 1 As shown, including: n LC oscillator sensing units on CMOS chip, n switched capacitors for in-situ self-calibration of LC oscillator, power management module (LDO), buffer, encoder / decoder, frequency mixer device, low-pass filter, and off-chip frequency counter; wherein, n switched capacitors and n LC oscillator sensing units form a sensor microarray (n is 20 in this embodiment), and each LC oscillator...

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Abstract

The invention discloses an LC oscillator magnetosensitive biosensor based on the on-chip switched capacitor in-situ self-calibration technology, which belongs to the technical field of biosensors. The sensor includes: n LC oscillator sensing units on a CMOS chip, n LC oscillator in-situ self-calibration switch capacitor, power management module, buffer, encoder / decoder, mixer, low-pass filter, and off-chip frequency counter; among them, n switch capacitors and n LC oscillators Sensor sensing units form a sensor microarray, n is a positive integer; the output of each LC oscillator sensing unit is connected to a switched capacitor. On the basis of achieving a good noise suppression effect, the chip area is saved, the cost and complexity are reduced, and the detection sensitivity is improved. After tape-out experiments, all indicators of biochips using this in-situ calibration technology have reached the highest level of similar technologies.

Description

technical field [0001] The invention belongs to the technical field of biosensors, in particular to an inductance-capacitance (LC) oscillator magnetic-sensitive biosensor based on an on-chip switched capacitor in-situ self-calibration technology. Background technique [0002] Immunoassay is an analytical method for the determination and analysis of specific detection substances (drugs, hormones, proteins, microorganisms, etc.) based on the specific reaction between antigens and antibodies. In the immune reaction, the extremely low detection concentration limit and unique selectivity of the immunoassay reagents make this analysis method widely used in the fields of clinical testing, biopharmaceuticals and environmental chemistry. Clinical medical research shows that there is a clear correspondence between many biomarkers (proteins, DNA, lipids, sugars, etc.) The detection of these biomarkers at trace concentrations (pg / ml) is of great significance for the early prevention an...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/02
Inventor 张雷耿金文钱鹤
Owner TSINGHUA UNIV
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