Application of medicine containing catechin to preparation of antibacterial medicines

A catechin and drug technology, applied in the field of medicine, can solve the problems of narrow therapeutic range, poor selectivity of antibacterial drugs, side effects of therapeutic drugs, etc., achieve broad antibacterial spectrum and reduce the probability of superinfection

Active Publication Date: 2016-01-13
王孝仓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the technical defects of poor selectivity of antibacterial drugs, narrow therapeutic range, and side effects of th

Method used

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  • Application of medicine containing catechin to preparation of antibacterial medicines
  • Application of medicine containing catechin to preparation of antibacterial medicines
  • Application of medicine containing catechin to preparation of antibacterial medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: catechin antibacterial effect experiment on Candida albicans

[0037] -,equipment

[0038] Test strain: against Candida albicans (ATCC10231), provided by China General Microorganism Culture Collection Center, the 4th generation.

[0039] Test sample: catechin aqueous solution (concentration 5g / L)

[0040] Phosphate buffered saline (PBS0.03moL / L, pH7.2)

[0041] Medium: Sabouraud agar medium.

[0042] 2. Method

[0043] Inspection basis: GB15979-2002.

[0044] Testing conditions: the test environment temperature is 20°C, and the number of repetitions is 3 times.

[0045] 3. Experimental results

[0046] The antibacterial effect is shown in the table below:

[0047] Table 1 The results of the antibacterial effect of catechin on Candida albicans

[0048]

[0049] Note: The number of bacteria in the positive control group was 5.35×104cfu / mL (4.8×104~5.8×104cfu / mL).

[0050] 4. Conclusion

[0051] According to GB15979-2002 "Hygienic Standards for Dis...

Embodiment 2

[0052] Embodiment 2: catechin antibacterial effect experiment on Escherichia coli

[0053] (-)equipment

[0054] Test strain: Escherichia coli (8099), provided by the Disinfection Testing Center of the Academy of Preventive Medicine, the 4th generation

[0055] Test sample: catechin aqueous solution (concentration 3g / L)

[0056] Phosphate buffered saline (PBS0.03moL / L, pH7.2)

[0057] Medium: Nutrient agar medium.

[0058] (2) Method

[0059] Inspection basis: GB15979-2002

[0060] Testing conditions: test environment temperature 20°C, repeat times 3 times

[0061] (3) Experimental results

[0062] The antibacterial effect is shown in the table below:

[0063] Table 2 catechins to Escherichia coli antibacterial effect experimental results

[0064]

[0065] Note: The number of bacteria in the positive control group was 4.11×104cfu / mL (3.76×104~4.38×104cfu / mL).

[0066] 4. Conclusion

[0067] According to GB15979-2002 "Hygienic Standards for Disposable Hygienic Prod...

Embodiment 3

[0068] Embodiment 3: The antibacterial effect experiment of catechin on Escherichia coli

[0069] 1. Equipment

[0070] Test strain: Staphylococcus aureus (ATCC6538), provided by China General Microorganism Culture Collection Center, the 4th generation.

[0071] Test sample: catechin aqueous solution (concentration 8g / L)

[0072] Phosphate buffered saline (PBS0.03moL / L, pH7.2)

[0073] Medium: Nutrient agar medium.

[0074] 2. Method

[0075] Inspection basis: GB15979-2002

[0076] Testing conditions: test environment temperature 20°C, repeat times 3 times

[0077] 3. Experimental results

[0078] The antibacterial effect is shown in the table below:

[0079] Table 3 catechins to Staphylococcus aureus antibacterial effect experimental results

[0080]

[0081] Note: The number of bacteria in the positive control group was 3.67×104cfu / mL (3.24×104~4.08×104cfu / mL).

[0082] 4. Conclusion

[0083] According to GB15979-2002 "Hygienic Standards for Disposable Sanitary ...

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Abstract

The invention provides application of a medicine containing catechin shown in formula (I) or catechin polymorphs to preparation of antibacterial medicines. Through experiment research, the catechin is wide in antibacterial spectrum and has exact inhibiting effect on various pathogenic microorganisms such as staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and hemolytic streptococcus; meanwhile, the catechin has good selectivity and has no irritation to normal flora and vagina mucosa, thereby being promising in application prospect on preparation of the antibacterial medicines. Formula (I).

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of medicines including catechins in the preparation of antibacterial medicines. Background technique [0002] The female reproductive organs are naturally warm and humid, which is easy to breed microorganisms. Under normal circumstances, the body's self-heating structure and chemical environment can play a protective role, so as to avoid pathological changes. On the one hand, the labia majora on both sides of the vulva are naturally closed to cover the vaginal opening, making it difficult for foreign microorganisms to enter; outside pollution. On the other hand, under the influence of estrogen, vaginal epithelial cells continue to metabolize, proliferate and thicken, increasing the resistance to pathogens; at the same time, under the action of vaginal bacillus, the glycogen rich in vaginal epithelial cells can be decomposed into Lactic acid, in order to maintain the...

Claims

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Application Information

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IPC IPC(8): A61K31/353C07D311/62A61P15/02A61P31/04
CPCY02A50/30
Inventor 王孝仓
Owner 王孝仓
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