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Nano-silver preparation for inhibiting mould Gra04 growth and preparation method thereof

A nano-silver and preparation technology, applied in the field of clinical medicine, can solve the problems of limited popularization and application, instability, etc., and achieve the effect of good killing and inhibition, long-lasting effect, and treatment of complications.

Inactive Publication Date: 2016-01-27
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver ions, Ag + Instability in solution limits its popularization and application

Method used

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  • Nano-silver preparation for inhibiting mould Gra04 growth and preparation method thereof
  • Nano-silver preparation for inhibiting mould Gra04 growth and preparation method thereof
  • Nano-silver preparation for inhibiting mould Gra04 growth and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The plate colony counting method test of embodiment 1 nano-silver preparation to Gra04

[0020] The preparation method of nanometer silver preparation, comprises the following steps:

[0021] Step 1, will be equivalent to AgNO 3 The 0.1mol / L NaOH aqueous solution of 1.2 times (molar ratio) was added dropwise to 0.1mol / LAgNO 3 In aqueous solution, stirred to form Ag 2 O precipitation, leave standstill, incline supernatant liquid, repeat several times;

[0022] Step 2, measure the dilute ammonia water that mass fraction is 2% with graduated cylinder, add to above-mentioned Ag 2 During O precipitation, stir rapidly for about 5-10 minutes to obtain a clear and transparent solution;

[0023] Step 3, will be equivalent to AgNO 3 PVP with 5 times, 7 times and 9 times the mass was added to the above solution, marked as sample one (m (AgNO3) =3.264g), sample two (m (AgNO3) =19.04g), sample three (m (AgNO3) =71.41g), after mixing evenly, place in the photochemical reactio...

Embodiment 2

[0026] The nano-silver preparation of embodiment 2 same particle size different concentrations is to the determination test of Gra04 antibacterial rate

[0027] The preparation method of nanometer silver preparation, comprises the following steps:

[0028] Step 1, will be equivalent to AgNO 3 The 0.1mol / L NaOH aqueous solution of 1.2 times (molar ratio) was added dropwise to 0.1mol / LAgNO 3 In aqueous solution, stirred to form Ag 2 O precipitation, leave standstill, incline supernatant liquid, repeat several times;

[0029] Step 2, measure the dilute ammonia water that mass fraction is 2% with graduated cylinder, add to above-mentioned Ag 2 During O precipitation, stir rapidly for about 5-10 minutes to obtain a clear and transparent solution;

[0030] Step 3, will be equivalent to AgNO 3 9 times the mass of PVP was added to the above solution, marked as sample one (m (AgNO3) =6.58g), sample two (m (AgNO3) =4.93g), sample three (m (AgNO3) =3.26g), sample four (m (AgNO3)...

Embodiment 3

[0035] The determination experiment of the nano-silver preparation of the same concentration different particle diameters to Gra04 antibacterial rate of embodiment 3

[0036] The preparation method of nanometer silver preparation, comprises the following steps:

[0037] Step 1, will be equivalent to AgNO 3 The 0.1mol / L NaOH aqueous solution of 1.2 times (molar ratio) was added dropwise to 0.1mol / LAgNO 3 In aqueous solution, stirred to form Ag 2 O precipitation, leave standstill, incline supernatant liquid, repeat several times;

[0038] Step 2, measure the dilute ammonia water that mass fraction is 2% with graduated cylinder, add to above-mentioned Ag 2 During O precipitation, stir rapidly for about 5-10 minutes to obtain a clear and transparent solution;

[0039] Step 3, will be equivalent to AgNO 3 PVP with 5 times, 7 times and 9 times the mass was added to the above solution, marked as sample sample one (m (AgNO3) =4.93g), sample two (m (AgNO3) =28.75g), sample three...

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Abstract

The invention discloses a nano-silver preparation for inhibiting mould Gra04 growth and a preparation method thereof. The particle size of nano-silver in the nano-silver preparation is 10-40 nm; and the concentration of the nano-silver is 4.04*10-5 mol / L-16.16*10-5 mol / L. The preparation method comprises the following steps: firstly, NaOH water solution is added in AgNO3 water solution for stirring; supernatant is removed; then, dilute ammonia solution is added in obtained Ag2O precipitation for stirring; finally, PVP is added in obtained mixed liquid for stirring, is positioned in an photochemical reaction instrument for reacting and centrifugating; and the obtained precipitation is the nano-silver preparation.

Description

technical field [0001] The invention belongs to the technical field of clinical medicine, and in particular relates to a nano-silver preparation for inhibiting the growth of mold Gra04 and a preparation method thereof. Background technique [0002] Aspergillus is a kind of opportunistic pathogenic fungus, which widely exists in nature. Among them, Aspergillus fumigatus is the main pathogen, accounting for 80% of Aspergillus. It is the pathogen of serious fungal secondary infection in patients with leukemia and advanced tumors, and its incidence rate is second only to that of Aspergillus. In candidiasis albicans. On the other hand, acute systemic or disseminated infection caused by Aspergillus fumigatus seriously threatens the life of immunocompromised patients, often with poor prognosis, and the mortality rate is as high as 50% or even 100%. In recent years, with the use of invasive treatments, bone marrow transplantation, and the abuse of broad-spectrum antibiotics, Asperg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B82Y40/00
Inventor 魏昂方婷吴家根陆玲刘飞飞
Owner NANJING UNIV OF POSTS & TELECOMM
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