Application of antrodia camphorata compound in preparation of drug for treating kidney diseases

A kidney disease and compound technology, applied in the field of application of Antrodia camphorata compounds in the preparation of drugs for the treatment of kidney diseases, can solve the problems of uncontrollable immune response side effects, unclear effects, etc.

Inactive Publication Date: 2016-02-10
曾卉菱
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although glucocorticoid steroid (glucocorticoid steroid) has been widely used in the treatment of IgAN patients, its effect on maintaining renal function and reducing proteinuria in IgAN is still unclear, and the potential uncontrollable immunosuppression caused by long-term use Side effects of reactions, still causing problems with medication

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  • Application of antrodia camphorata compound in preparation of drug for treating kidney diseases
  • Application of antrodia camphorata compound in preparation of drug for treating kidney diseases
  • Application of antrodia camphorata compound in preparation of drug for treating kidney diseases

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Embodiment Construction

[0021] The present invention mainly aims at a compound extracted from Antrodia camphorata, and detects whether it has the effect of treating kidney disease and anti-inflammation of the kidney. Antrocamol LT3 is a new compound discovered by the inventors, and the relevant extraction and structural identification data of LT3 will be provided below.

[0022] Extraction of Antrodia Antrodia

[0023] Take Antrodiacamphorata (Antrodiacamphorata) mycelia, fruiting bodies or a mixture of the two (1.0kg) and extract twice with 10 times the amount of alcohol, combine and concentrate to obtain about 230g of crude extract (LT-E), and the crude extract is obtained with Dichloromethane / water (1:1) carried out the distribution extraction method 3 times, divided into about 102.6g of dichloromethane layer (LT-E-D) and about 127.4g of water layer (LT-E-W), and took 6.0g of dichloromethane layer It is separated into ANCA-E-D-1 and ANCA-E-D-2 by silica gel column chromatography through n-hexane / ...

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Abstract

The invention discloses an application of an antrodia camphorate compound in preparation of a drug for treating kidney diseases, wherein the compound is represented as the formula (I) and the kidney diseases is glomerulosclerosis or glomerulonephritis.

Description

technical field [0001] The present invention relates to the medical use of a compound isolated from Antrodia cintrodia, in particular to the use of an Antrodia cintrodia compound in the preparation of medicines for treating kidney diseases. Background technique [0002] Antrodiacamphorata, also known as Antrodia camphorata, Antrodia camphorata, or Antrodia red, belongs to the perennial fungi of the order Aphyllophorales and the family Polyporaceae. It is a unique species of fungi in Taiwan and only grows in Taiwan. On the inner wall of the hollow decaying heartwood of the conservation tree species-Cinnamoumkanehirai Hay. Due to the extremely rare distribution of Cinnamomum camphora and man-made poaching, the number of wild Antrodia camphorata parasitic in it is even rarer, and because its fruiting body grows very slowly, the growth period is only between June and October , and therefore very expensive. In Taiwanese folk medicine, Antrodia Cinnamomea has the functions of de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P13/12A61P29/00
Inventor 张温良姚振文严逸钊曾卉菱曾宛平曾泰霖郭盈妤
Owner 曾卉菱
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