Method and system for assessing health condition

A biomarker and target technology, applied in the field of computer-aided systems for assessing whether a subject mammal has a target disease, computer-readable media for assessing whether a test mammal has a target disease, capable of solving insufficient data points and difficult results Comparison and other issues, to achieve the effect of sensitive measurement, reproducible measurement

Active Publication Date: 2016-02-10
THE PROCTER & GAMBLE COMPANY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the results between different patients and different examiners are difficult to compare
Furthermore, despite the complexity of the oral microbiome and the suspected polymicrobial nature of chronic oral infections, population-wide investigations of the microbiota associated with gingivitis have been limited to only a few culturable bacteria (e.g. "red complex" including gingival Porphyromonas gingivalis, Tannerella forsythia, and Treponemadenticola), which provide insufficient data points for a complete analysis of the different microorganisms that can potentially cause gingivitis

Method used

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  • Method and system for assessing health condition
  • Method and system for assessing health condition
  • Method and system for assessing health condition

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[0113] The examples herein are intended to illustrate the invention but are not intended to limit or otherwise limit the scope of the invention.

[0114] acronym list :

[0115] NG: Naturally occurring gingivitis

[0116] EG: Experimental gingivitis

[0117] MGI: Modified / Mazza Gingival Index

[0118] BOP: bleeding on probing

[0119] MiGs: Microbial Gingivitis Index

[0120] RPM: Regression-Progression Model

[0121] PAM: segmentation algorithm around center point (clustering algorithm)

[0122] PCA: Principal Component Analysis

[0123] PCoA: Principal Coordinates Analysis

[0124] FDR: false discovery rate

[0125] COG: Clustering of Ortholog Groups

[0126] MiG: Microbial Gingivitis Index

[0127] MiG-S: Microbial Gingivitis Susceptibility Index

[0128] ROC: Receptor Action Characteristic

[0129] CI: confidence interval

[0130] KO: KEGG ortholog

[0131] Target Conditions and Biomarkers

[0132] The regression-progression model (RPM) was designed to s...

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Abstract

Provided is a method of assessing whether a subject mammal has a target condition, comprising a step of formulating a function of abundances of a first group of biomarkers and abundances of a second group of biomarkers that is useful for assessing whether the subject mammal has the target condition. Also provided are a computer-aided system for assessing whether a subject mammal has a target condition and a computer-readable medium for assessing whether a subject mammal has a target condition.

Description

technical field [0001] The present invention relates to methods of assessing whether a subject mammal has a condition of interest. The present invention also relates to a computer-aided system for assessing whether a subject mammal has a condition of interest. The invention also relates to computer readable media for assessing whether a subject mammal has a condition of interest. Background technique [0002] The health status of the subject is usually assessed based on a variety of symptoms. However, many symptoms used for health assessment today are misleading due to their subjective description and uncertain relationship to disease state. [0003] Often, an undesired condition begins as an asymptomatic disease that, if left untreated, progresses to a more serious condition. Detecting such diseases at an early stage can be difficult. Although doctors or other medical professionals are trained in disease detection, proper testing is time-consuming. Furthermore, quantif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G06F19/18G06F19/24C12Q1/02C12Q1/68G16B40/00G16B20/00G16B20/20
CPCC12Q1/02G01N33/68G01N2800/60C12Q1/689G16B20/00G16B40/00G16B20/20
Inventor 李睿黄适T·何刘吉泉徐健
Owner THE PROCTER & GAMBLE COMPANY
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