105results about How to "Sensitive measurement" patented technology

The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.

Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.

The invention is based on an HVAC (heating, ventilation and air-conditioning) system which comprises the following components: a) a fluid flow duct (1), b) a fluid flow valve (7) which is arranged therein and has a valve body (5) in the fluid flow duct (1) and a valve motor (15) which moves the valve body (5), c) a control circuit for activating the valve motor, d) a sensor (8) in the fluid flow duct (1) and e) an evaluation module for evaluating signals of the sensor. In order to produce an automated functional control, the following procedure is adopted: f) a first actuation signal is preset for the valve motor by the control circuit, and the actuation signal corresponds to a first setpoint position of the valve body (5), g) registration of a first signal of the sensor (8) by the evaluation module, and h) determination of a functional diagnosis of the fluid flow valve on the basis of the first signal of the sensor.

The invention is related to a laser diode based multiple beam laser spot imaging system for characterization of vehicle dynamics. A laser diode based, preferably VCSEL based laser imaging system is utilized to characterize the vehicle dynamics. One or more laser beams are directed to the road surface. A compact imaging system including an imaging matrix sensor such as a CCD or CMOS camera measures locations or separations of individual laser spots. Loading status of vehicles and vehicles' pitch and roll angle can be characterized by analyzing the change of laser spot locations or separations.

A detection system combines an excitation radiation source (18) providing excitation radiation (10) to an analysis region of a sample (14) within a substrate (16) having a detection surface, a detector (22) for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement (24) beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads (15) within the sample to the substrate surface The detection radiation is collected from the detection surface of the substrate, to give an enhanced surface specificity The invention combines the advantages of surface detection with a simple low cost magnetic system for bringing the target to the surface

In a microsensor with a micro-electromechanical sensor element and an integrated circuit for measuring, calibration and compensation electronics, whereby the sensor is connected electrically to the integrated circuit (IC), the micro-electromechanical sensor element is arranged directly on the integrated circuit with accurate positioning, and is connected with electric conductivity via a circulating soldered joint.

A non-invasive electro-optic probe and probe method for probing electric fields in semiconductor devices comprising directing laser output at a semiconductor device to be probed employing a laser having an operating wavelength such that photon energy of a second harmonic wavelength of the operating wavelength is below the band gap of a semiconductor comprised by the semiconductor device and detecting second harmonic wavelength but not operating wavelength radiation from the semiconductor device.

The present invention is directed to a non-immunogenic cellular composition comprising: a cell having a cell surface and antigenic determinants on the cell surface; an optional linker molecule covalently attached to the cell surface; and a hydrophilic, biocompatible, non-immunogenicity providing compound or polymer (e.g., polyethylene glycol or a derivative thereof) covalently attached to the linker molecule or directly to the cell. In one embodiment, the linker molecule is covalently attached directly to the antigenic determinant on the cell surface. In an alternate embodiment, the linker molecule may be covalently attached to a non-antigenic site on the cell surface, but will camouflage the antigenic determinant on the cell surface. Various uses of the resulting non-immunogenic cell are also provided, including a method of decreasing phagocytosis of a cell, a method of decreasing an adverse reaction to a transfusion, a method of decreasing rejection of a transplanted cell, tissue or organ, and a method of decreasing antibody-induced aggregation of cells.

A multi-well helium Dewar is provided for recirculating coolant about a cryostat probe; the Dewar includes a first well containing a first coolant reservoir, and a second well containing a second coolant reservoir. A fluid connection extends between the first and second coolant reservoirs. A low impedance conduit further connects a top end of the second well to the first well. In this regard, the Dewar at least partially contains a cryocooler within the first well and a cryostat probe within the second well. Vibrational noise is reduced by the incorporation of soft mounting components for connecting various features. A thermal shield of the Dewar can be thermally connected to isolated components for additional cooling power and increased efficiency during initialization. A second fluid connection may include a valve attached to a counter-flow heat exchanger for efficiently re-condensing excess gas within the Dewar.

A method of concentrating a gaseous substance includes the steps of isolating a trap in which an analyte to be concentrated has been absorbed from a carrier gas passed through the trap and reducing the pressure within the trap to a first pressure. The analyte is desorbed from the trap and the analyte released from the trap is diffused into an analyser operating at a second pressure lower than the first pressure.

The invention discloses a micro mechanical differential capacitive pressure gauge. Two capacitors of the pressure gauge are formed by three capacitive polar plates: an upper polar plate formed through depositing a metal on a glass sheet or a silicon wafer; a lower polar plate formed by heavily doped silicon and an intermediate movable polar plate which is partly connected with a pressure-sensitive membrane and formed by monocrystal silicon or polycrystalline silicon. The pressure gauge is based on a basic silicon cup structure in a pressure gauge structure, when a pressure is applied to the sensitive membrane, the membrane is deformed and the intermediate polar plate connected with the sensitive membrane is also deformed so that the capacitances of the upper and lower capacitors are changed and thus differential signal output is formed. The preparation process of the pressure gauge is simple and advantages of a differential structure can be used to realize differential detection of pressure.

A MEMS transducer configured to operate as a microphone, the MEMS transducer comprising a flexible membrane, the flexible membrane having a first surface and a second surface, wherein the first surface of the flexible membrane is fluidically isolated from the second surface of the flexible membrane. Also, a MEMS device comprising a MEMS transducer, an electronic device comprising a MEMS transducer and/or a MEMS device, and a method for forming a MEMS device.

The invention discloses an ultrashort pulse time width measurement device and method based on spectral interference. The device comprises a to-be-measured ultrashort pulse laser, a 50:50 beam splitter, a measurement optical path, a reference optical path, a beam combiner and a spectral analyzer. According to the method, a to-be-measured ultrashort pulse is divided into two to-be-measured ultrashort pulse beams with equal power; the to-be-measured ultrashort pulse beams are emitted to the beam combiner through the measurement optical path, time delay of the to-be-measured ultrashort pulse in the measurement optical path is regulated, and the polarization state of the to-be-measured ultrashort pulse in the measurement optical path is regulated to be matched with a to-be-measured ultrashort pulse in the reference optical path; the optical power of the to-be-measured ultrashort pulse in the reference optical path is regulated to be equal to the optical power of the to-be-measured ultrashort pulse output by the measurement optical path; and the change of the spectral interference oscillation degree of the to-be-measured ultrashort pulse is measured, and the time width of the to-be-measured ultrashort pulse is calculated. Through the ultrashort pulse time width measurement device and method, the mode of measuring frequency-doubled signal intensity of the to-be-measured ultrashort pulse based on a frequency doubling crystal in traditional ultrashort pulse time width measurement is abandoned, measurement sensitivity is high, and meanwhile good applicability is achieved.

The invention relates to a device for monitoring the temperature of an oil tank by FBGs (Fiber Bragg Grating) and belongs to the technical field of FBG detection. The device comprises an ABE (Amplified Spontaneous Emission) light source, a spectrum demodulation instrument, a computer and the like and is characterized in that the ASE light source is connected with the input end of a 3db coupler by an optical fiber; one output end of the 3db coupler is connected onto an optical switch by an optical fiber; the output end of the optical switch is connected with a splitter by an optical cable; the output end of the splitter is connected with a plurality of FBGs by optical cables; the other output end of the 3db coupler is connected onto the spectrum demodulation instrument by an optical fiber; the spectrum demodulation instrument is connected with the computer; and the computer is connected with an alarm. According to the device disclosed by the invention, the temperature calibration is firstly carried out and then the temperature of the oil tank is timely monitored; and the device has the advantages of rapidness, accuracy, sensitivity, safety and stability for measuring and capability of simultaneously measuring the oil temperature and the oil gas temperature by the computer and can replace an original complex measurement instrument easy to influence by external factors, so that the cost is reduced.

The invention relates to the determination of resistances of microorganisms which produce β-lactamases, in particular “extended spectrum β-lactamases” (ESBL). The invention provides a method whereby the microbial resistance can be measured very simply and quickly by means of the catalytic effect of the microbially produced β-lactamases on β-lactam antibiotics, which consists in a hydrolytic cleavage of the β-lactam ring. The method determines the resistance of the bacteria a few hours after a suitable substrate, either a β-lactam antibiotic or a customized β-lactam derivative, has been added to a suspension of the microbes, by direct mass spectrometric measurement of the substrate breakdown caused by the β-lactamases.

The invention belongs to the technical field of online monitoring of partial discharge of electric power paper oil insulation electrical equipment and relates to a method for detecting the partial discharge direction of a compound eye type optical fiber EFPI. A system for detecting the partial discharge direction of the compound eye type optical fiber EFPI is utilized; voltage signals output by five identical amplifiers are connected to an oscilloscope, power is supplied, a compound eye type optical fiber external cavity type Fabry-Perot sensor is placed at the top end of an insulating rod, and the insulating rod is rotated toward an optical fiber external cavity type Fabry-Perot sensing head with the strongest signal till the partial discharge pulse amplitude of an optical fiber external cavity type Fabry-Perot sensing head located in the middle is the largest and the partial discharge pulse amplitudes of optical fiber external cavity type Fabry-Perot sensing heads placed on the periphery are roughly equal; then, the orientation of the optical fiber external cavity type Fabry-Perot sensing head located in the middle in the compound eye type optical fiber external cavity type Fabry-Perot sensor is the direction of the partial discharge point. The method is high in sensitivity, good in directivity and high in anti-interference capacity and can be used for locating the partial discharge direction of key portions of electrical equipment conveniently and accurately.

A method for ionizing, using pulses of ionization radiation, an analyte to be examined by way of ion mobility spectrometry using a pulse sequence is modulated with a known time-variable impression pattern is provided. An ionization device for carrying out the method and an ion mobility spectrometry method and an ion mobility spectrometry device that use the ionization method and/or the ionization device are also provided.