Measuring device and method of spatial distribution of scattering light field of immunochromatographic test strip
An immunochromatographic test strip and immunochromatography technology are applied in the field of measuring devices for the spatial distribution of scattered light fields, and can solve the problems that the immunochromatographic test strips cannot be used to measure the spatial distribution of scattered light fields, and the intensity of light fields cannot be measured.
Active Publication Date: 2016-02-24
上海镭慎光电科技有限公司
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Problems solved by technology
In addition, prior art 1 and prior art 2 cannot measure the light field intensity in a certain continuous area
Therefore, the devices in prior art 1 and prior art 2 cannot be used to measure the spatial distribution of scattered light field of immunochromatographic test strips
[0005] Prior technology 3 (Ding Jue. Establishment and application of multi-parameter spectral measurement method for turbid media. Academy of Military Medical Sciences of the Chinese People's Liberation Army. 2014.) and prior technology 4 (YunT, ZengN, LiW, etal. Monte Carlosimulation of polarized photoscatteringinanisotropic media. [J ]. OpticsExpress, 2009, 17(19): 16590-16602.) The experimental device can only measure the light intensity of a certain fixed position or some fixed positions in space under different incident angles, but cannot measure the light intensity of the fixed position. Light field intensity in a continuous area
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[0062] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the protection scope of the present invention is not limited thereby.
[0063] see figure 1 and figure 2 , figure 1 It is a structural block diagram of the device for measuring the spatial distribution of the scattered light field of the immunochromatographic test strip of the present invention, figure 2 It is an optical path diagram of the device for measuring the spatial distribution of the scattered light field of the immunochromatographic test strip of the present invention. It can be seen from the figure that the measurement device for the spatial distribution of the scattered light field of the immunochromatography test strip of the present invention is mainly composed of an illumination light path mechanism 1, a reference light path mechanism 2, an incident light path mechanism 3, a two-dimensional tilting platform 4, a scattering light pat...
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Abstract
A measuring device and method of spatial distribution of scattering light field of an immunochromatographic test strip are provided. The measuring device comprises an illumination optical path mechanism, a reference optical path mechanism, an incidence optical path mechanism, a two-dimensional sloping platform used for placing an immunochromatographic test strip to be measured, a scattering optical path mechanism, a three-dimensional translational platform, and a data acquisition and control system. The measuring device and method can eliminate the influence of light source instability, change the incidence angle of the immunochromatographic test strip, so that the whole device can measure the spatial distribution of scattering light field in different incidence angles, the scattering light field in a continuous area at different spatial points in the same incidence angle can be measured, and the measuring of scattering light field of turbid media can be met. The ratio of the relative fluorescent light field intensity to the relative exciting light field intensity is used for the same spatial point. The measuring device and method provide a powerful tool to improve the signal-to-noise ratio of the immunochromatography apparatus.
Description
technical field [0001] The invention relates to the measurement of the spatial distribution of the scattered light field, in particular to a measuring device and method for the spatial distribution of the scattered light field of an immunochromatography test strip. Background technique [0002] In vitro diagnostic technology with immunochromatographic test strips as the detection object is an important branch of POCT technology. The functional strip of the immunochromatographic test strip is attached with a fluorescent particle-analyte complex. When the incident laser is irradiated on the functional strip of the immunochromatographic test strip, an excitation light scattering light field and a fluorescent light field are formed in space. . The immunochromatography detection instrument can detect the concentration of the analyte on the immunochromatography test strip by collecting fluorescence. In order to obtain a high-performance immunochromatographic detection instrument...
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IPC IPC(8): G01N33/53G01N21/64G01N21/49
CPCG01N21/49G01N21/6402G01N33/53
Inventor 黄立华肖阳胡卓非何薇羽凌丽青郭凯黄惠杰
Owner 上海镭慎光电科技有限公司