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Biomarkers for the prognosis of lung cancer and their uses

A prognostic and lung cancer technology, applied in biological testing, biochemical equipment and methods, microbial measurement/testing, etc., can solve problems such as deviation and inability to be widely verified

Inactive Publication Date: 2019-02-05
陈铁华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of them are based on small samples or data limited to a single research institution, and ultimately cannot be widely verified in different data from different countries
Moreover, a considerable number of authors clearly have more than 10 years of follow-up data, but only compare the change of survival period of 5 years, which will undoubtedly bring about greater bias

Method used

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  • Biomarkers for the prognosis of lung cancer and their uses
  • Biomarkers for the prognosis of lung cancer and their uses
  • Biomarkers for the prognosis of lung cancer and their uses

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Embodiment Construction

[0033] The technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. The following description of at least one exemplary embodiment is merely illustrative in nature and in no way taken as limiting the invention, its application or uses. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0034] Techniques and methods known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, such technical industry methods and methods are considered part of the Authorized Specification.

[0035] All documents mentioned in this application are incorporated by reference in this application as if each were in...

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Abstract

The present invention relates to biomarkers for prognosis of lung cancer. The inventor analyzed the gene expression microarray (GEP) data of 2,738 cases of lung cancer from multiple countries, and used statistical analysis methods to screen out 95 specific genes for the prognosis of lung cancer, of which 85 genes were first reported and related to lung cancer. The probability of survival is related to the probability of recurrence after surgery. The 95 genes were further subjected to univariate analysis, multivariate analysis and survival curve analysis, and finally 7 representative genes were screened out more accurately. The clinical data of lung cancer in many countries have proved that these specific gene markers can be very effectively used to predict the survival and recurrence rate of lung cancer patients, and patients can be divided into low, medium and high risk groups accordingly.

Description

technical field [0001] The invention relates to the field of prognosis of lung cancer, mainly the prediction of survival probability and postoperative recurrence probability of lung cancer. More specifically, the present invention relates to biomarkers for lung cancer prognosis and uses thereof. Background technique [0002] According to the report of CA: A Cancer Journal for Clinicians (2013; 63:11-30), the most authoritative medical journal in the world, there were 1.66 million new cases of cancer in the United States in 2013, and 580,000 people died of cancer. Among them, the mortality rate of lung cancer ranks first, with 163,000 people dying of lung cancer every year, and 246,000 new cases of lung cancer every year. Based on the estimate of 246,000 new lung cancer cases in the United States with a population of 310 million people, the number of new lung cancer cases in China with a population of 1.38 billion should be 1,095,000. [0003] "2012 China Cancer Registratio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886G01N33/68C12N15/11C07K14/435
CPCC12Q1/6886G01N33/68C12Q2600/158C12Q2600/112C12Q2600/106C12Q2600/16C12Q2600/118
Inventor 陈铁华陈潞铭凌静
Owner 陈铁华
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