Liver normal temperature perfusion restoration system

Abstract

The invention discloses a liver normal temperature perfusion restoration system. The system comprises a liver container. The liver container comprises a main body and an upper cover. The main body and the upper cover are fastened tightly. A silica gel flexible net is fixed to the main body of the liver container. The lower end of the main body of the liver container is provided with a blood return channel. The blood return channel is connected to a centrifugal pump by a blood storage tank. The front end of the blood storage tank is provided with a filter film. An outlet end of the centrifugal pump is connected to an oxygenator. The oxygenator is connected to an oxygen control device. A blood pipe of the oxygenator is divided into two paths by a heat exchanger, one path is used for hepatic artery perfusion by a roller pump and the other path is used for direct portal vein perfusion. Liver artery forms a pulsatile blood flow under the action of the roller pump so that physiological liver artery perfusion is simulated and bile duct cell protection is realized in perfusion. The system can keep hepatocyte aerobic metabolism at a normal temperature, realizes short-time restoration treatment on the liver and widens a liver source.

Description

technical field [0001] The invention relates to a liver perfusion repair system at normal temperature. Background technique [0002] Liver transplantation is the only effective way to save end-stage liver disease. As the demand for liver transplantation increases year by year, the shortage of donor livers is also becoming more and more obvious, seriously restricting its development. Marginal donor livers or extended standard donor livers (ECD) are gradually included in the selection range, including fatty liver, advanced age, and cardiac death donors (DCD). With the standardization of the domestic organ donation system, DCD liver transplantation has increased year by year, but the average age of this type of donors is relatively high, and the proportion of hepatic steatosis has also increased accordingly. According to statistics, the detection rate of fatty liver in liver transplant donors is close to 30%, and nearly 50% of discarded donor livers are fatty liver. Moderate...

AI Technical Summary

Problems solved by technology

[0007] The disadvantage of this method is that the pressure and flow of the portal vein, the main blood supply to nourish the liver, are regulated by the liquid level in the blood storage bag. During the perfusion process, the resistance of the portal vein is greatly affected by the intrahepatic microcirculation. The flow and pressure will change in real time, and it is difficult to maintain a stable perfusion cycle by adjusting the speed of the centrifugal pump and the valve at the inlet of the blood storage bag

Once the liquid level is low, the portal pressure will drop, the flow rate will increase, the liquid level will drop further, air will enter the circulation system and the centrifugal pump will stop working, and finally the test will fail

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