Liver normal temperature perfusion restoration system

A technology for repairing system and liver, applied in the field of liver perfusion repairing system at room temperature, can solve problems such as difficulty in maintaining perfusion cycle stability, test failure, drop, etc., and achieve the effect of avoiding compression deformation, easy operation, and ensuring purity

Inactive Publication Date: 2016-03-09
ZHEJIANG UNIV
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Problems solved by technology

[0007] The disadvantage of this method is that the pressure and flow of the portal vein, the main blood supply to nourish the liver, are regulated by the liquid level in the blood storage bag. During the perfusion process, the resistance of the portal vein is greatly affected by the intrahepatic microcirculation. The flow and pressure will change in real time, and it is diff

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  • Liver normal temperature perfusion restoration system
  • Liver normal temperature perfusion restoration system

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[0027] Referring to the attached figure, put the donor liver 1 on the silicone soft net, fix the silicone soft net on the edge of the liver container body, ligate the superior and inferior hepatic vena cava, and insert the inferior hepatic vena cava so that blood from the hepatic vein can flow smoothly into the vena cava. directly into the blood storage tank 11, and a small amount of hepatic porta oozing blood flows into the blood storage tank through the blood return channel at the lower end of the liver container. The blood storage tank is equipped with a filter membrane to filter impurities such as cell debris and microthrombi in the blood. The infusion pump 9 is connected with the blood storage tank to provide nutrition and drug cell therapy for the hepatic circulation. The blood storage tank is connected with the centrifugal pump 3, and the centrifugal pump is responsible for the total hemodynamic output. The blood output by the centrifugal pump is transported to the oxy...

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Abstract

The invention discloses a liver normal temperature perfusion restoration system. The system comprises a liver container. The liver container comprises a main body and an upper cover. The main body and the upper cover are fastened tightly. A silica gel flexible net is fixed to the main body of the liver container. The lower end of the main body of the liver container is provided with a blood return channel. The blood return channel is connected to a centrifugal pump by a blood storage tank. The front end of the blood storage tank is provided with a filter film. An outlet end of the centrifugal pump is connected to an oxygenator. The oxygenator is connected to an oxygen control device. A blood pipe of the oxygenator is divided into two paths by a heat exchanger, one path is used for hepatic artery perfusion by a roller pump and the other path is used for direct portal vein perfusion. Liver artery forms a pulsatile blood flow under the action of the roller pump so that physiological liver artery perfusion is simulated and bile duct cell protection is realized in perfusion. The system can keep hepatocyte aerobic metabolism at a normal temperature, realizes short-time restoration treatment on the liver and widens a liver source.

Description

technical field [0001] The invention relates to a liver perfusion repair system at normal temperature. Background technique [0002] Liver transplantation is the only effective way to save end-stage liver disease. As the demand for liver transplantation increases year by year, the shortage of donor livers is also becoming more and more obvious, seriously restricting its development. Marginal donor livers or extended standard donor livers (ECD) are gradually included in the selection range, including fatty liver, advanced age, and cardiac death donors (DCD). With the standardization of the domestic organ donation system, DCD liver transplantation has increased year by year, but the average age of this type of donors is relatively high, and the proportion of hepatic steatosis has also increased accordingly. According to statistics, the detection rate of fatty liver in liver transplant donors is close to 30%, and nearly 50% of discarded donor livers are fatty liver. Moderate...

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0247
Inventor 张启逸段继轩吴劲进田阳屠振华严盛姜建杰钱林峰施丽萍陈辉周琳谢海洋王伟林郑树森
Owner ZHEJIANG UNIV
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