Application of bitter orange volatile oil extract in preparation of antidepressant drug

Abstract

The invention provides an application of a bitter orange volatile oil extract in preparation of an antidepressant drug. The bitter orange volatile oil extract is extracted from a bitter orange medicinal material, and a main component is limonene. An extraction technology of the bitter orange volatile oil extract comprises steps as follows: the bitter orange medicinal material is taken and soaked for 1-3 h, a steam distillation method is adopted, 6-10 times of water in volume is added for extraction for 5-9 h, and the bitter orange volatile oil extract is obtained. A preferable technology comprises steps as follows: the bitter orange medicinal material is taken and soaked for 3 h, the steam distillation method is adopted, 8 times of water in volume is added for extraction for 7 h, and the bitter orange volatile oil extract is obtained. Multiple preparations can be prepared from the bitter orange volatile oil extract, and the bitter orange volatile oil extract can be applied to development of a clinical new antidepressant drug after addition of pharmaceutically acceptable auxiliary materials and carriers. According to the application of the bitter orange volatile oil extract in preparation of the antidepressant drug, in-vitro pharmacological experiments prove that the bitter orange volatile oil extract has a protection effect on hypoxia-injury SH-SY5Y nerve cells, has a remarkable anti-depression function and lays the foundation for development of the new antidepressant drug.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the application of the volatile oil extract of Fructus Fructus Citrus Fructus as an antidepressant medicine. Background technique [0002] Depression is a mental and emotional disorder with persistent low spirits as the main symptom. The clinical treatment of depression mainly relies on western medicine antidepressants, supplemented by psychotherapy, but this treatment method has disadvantages such as slow onset of effect, long course of treatment, large side effects, and high drug price. In recent years, traditional Chinese medicine has gained rich experience and good curative effect in the experimental research of treating depression. According to a large number of literature surveys, many traditional Chinese medicine compound prescriptions, single herbal medicines and active ingredients of traditional Chinese medicine have antidepressant effects. Therefo...

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Problems solved by technology

At present, there is no report on the antidepressant research of the volatile oil of Fructus Aurantii

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