Method for treating and/or improving male erectile dysfunction by using low-intensity pulsed ultrasound

A technology of erectile dysfunction and pulsed ultrasound, which is applied in ultrasound therapy and treatment, and can solve problems such as lack of low-intensity pulsed ultrasound

Inactive Publication Date: 2016-07-06
北京东方百奥医药开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far there is no research report on the application of low-intensity pulsed ultrasound in the prevention and treatment of male erectile dysfunction

Method used

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  • Method for treating and/or improving male erectile dysfunction by using low-intensity pulsed ultrasound
  • Method for treating and/or improving male erectile dysfunction by using low-intensity pulsed ultrasound
  • Method for treating and/or improving male erectile dysfunction by using low-intensity pulsed ultrasound

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 Implementation method of low-intensity pulsed ultrasound treatment equipment for treating male erectile dysfunction

[0055] 1. The present invention provides a low-intensity pulsed ultrasonic treatment device for treating male erectile dysfunction.

[0056] figure 1 It is a structural diagram of the low-intensity pulsed ultrasonic treatment equipment for treating male erectile dysfunction provided by the present invention, wherein 1 shows the main control system; 2 is the micro-control system; 3 is the treatment probe.

[0057] The main control system includes a computer and a main power supply module. Among them, the computer provides a window for man-machine dialogue, and can control the output power, the selection of treatment gear, the setting of treatment time, etc.

[0058] image 3 It is the physical picture of the micro-control system of the low-intensity pulsed ultrasonic treatment equipment for the treatment of male erectile dysfunction provid...

Embodiment 2

[0072] Example 2 The therapeutic effect of low-intensity pulsed ultrasound on erectile dysfunction caused by diabetes

[0073] 1. Establishment of diabetic erectile dysfunction rat model

[0074] In recent years, diabetes has gradually become an important cause of erectile dysfunction, and the rat model of diabetic erectile dysfunction is one of the most commonly used and reasonable models.

[0075] The inventor used 75 8-week-old male SD rats and divided them into a normal group (N, 15 rats) and a diabetic group (DM, 60 rats). After fasting for 16 hours, the rats in the DM group were intraperitoneally injected with streptozotocin (60 mg / Kg) to induce the type I diabetic rat model. On the third day, the blood glucose was continuously detected, and the type I diabetes model was considered successful when the blood glucose was continuously higher than 16.7mmol / L. Erectile dysfunction can appear 4 weeks after successful induction of type I diabetes in rats.

[0076] A. Experim...

Embodiment 3

[0111] The safety animal experiment of embodiment 3 low-intensity pulsed ultrasound

[0112] 1. Experimental design

[0113] The inventor used 60 8-week-old male SD rats and divided them into a normal group (N, 15 rats) and a low-intensity pulsed ultrasonic treatment group (LIPUS, 45 rats).

[0114] A. Experimental grouping (the following treatment schemes are static applications)

[0115] a. NC control group (15 rats): During treatment, the ultrasound probe was only in contact with the penis, but there was no energy output.

[0116] b. NC+LIPUS100 group (15 rats): The natural frequency of ultrasonic waves is 1.7MHz, the pulse frequency is 1000Hz, the output intermittent ratio is 200μs / 800μs, and the intensity is 100mW / cm 2 , each treatment time is 3min, 3 times / week (once every 2-3 days, the same below), and the treatment lasts for 2 weeks.

[0117] c.NC+LIPUS300 group (15 rats): the natural frequency of ultrasonic waves is 1.7MHz, the pulse frequency is 1000Hz, the output...

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Abstract

The invention relates to a method for treating and/or improving male erectile dysfunction by using low-intensity pulsed ultrasound. According to the method of the invention, as proved by experiments, low-intensity pulsed ultrasound therapy can repair corpus cavernosum vascular endothelial cell functions so as to promote corpus cavernosum smooth muscle cell proliferation, promote eNOS and nNOS expression, improve penile blood flow, lower a TGF-beta 1/Smad/CTGF signal pathway and reduce penile fibrosis, and thereby, improving penile pathological change and ultimately achieving erectile dysfunction treatment effects.

Description

technical field [0001] The invention relates to a method for treating and / or improving male erectile dysfunction, in particular to a method for using low-intensity pulsed ultrasound to treat and / or improve male erectile dysfunction. Background technique [0002] Male sexual function includes sexual desire, penile erection, ejaculation and sexual pleasure. It is a complex physiological response involving the nervous, endocrine and vascular systems. Sexual dysfunction includes loss of libido, erectile dysfunction, and ejaculation disorders. Erectile dysfunction refers to that when a man has a sexual desire, the penis cannot be erected or the erection is not hard enough to insert into the vagina or the duration of sexual intercourse is not long enough to complete a satisfactory sexual life. Erectile dysfunction is a common disease in andrology, and its incidence accounts for about 50% of adult males. There are about 150 million men in the world suffering from erectile dysfunct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/02
Inventor 辛钟成郭应禄郭素梅林倩玉辛华田贞姬
Owner 北京东方百奥医药开发有限公司
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