Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A dual-mode simultaneous tomographic imaging method of CT and X-ray excited fluorescence

A technique of exciting fluorescence and tomography, which is applied in the fields of radiological diagnostic instruments, diagnostics, medical science, etc., can solve the problems of long time, complicated process, high dose, etc., to reduce morbidity, reduce radiation dose, and reduce the number of rotations Effect

Active Publication Date: 2018-12-28
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a dual-mode simultaneous tomographic imaging method of CT and X-ray excited fluorescence, aiming to solve the problems of separate acquisition, complicated process, high dose and long time of CT / XLCT dual-mode imaging

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A dual-mode simultaneous tomographic imaging method of CT and X-ray excited fluorescence
  • A dual-mode simultaneous tomographic imaging method of CT and X-ray excited fluorescence
  • A dual-mode simultaneous tomographic imaging method of CT and X-ray excited fluorescence

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0043] The application principle of the present invention will be further described below in conjunction with specific embodiments.

[0044] The CT / XLCT dual-mode imaging system of our laboratory was used to simultaneously acquire the CT and XLCT projection data of the phantom. The X-ray source of the system is the micro-focus spot X-ray source (UltraBright, Oxford Instruments, and U.K.) of Oxford Instruments, the X-ray flat panel detector is Dexela 2923 (Dexela 2923CMOS X-ray detector), and the CCD camera adopts electron multiplying CCD ( iXon DU-897, Andor, United Kingdom). The system uses the rotation of the turntable ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a CT and X-ray luminescence computed dual-mode synchronous tomography method. Small animal X-ray luminescence computed tomography and computed tomography (CT) can be achieved synchronously, and a more accurate imaging object anatomical structure and molecular imaging information are provided. It is guaranteed that an XLCT projection and a CT projection are collected at the same location and same time by reducing the CT projection angle number and setting the CT projection angle number to be the same as that of the XLCT or be in a diploid relation with that of the XLCT; meanwhile, by means of a compressive sensing principle, a few-angle reconstruction algorithm achieving image total variation minimization is adopted for the CT projection, and a precondition matrix and wavelet transformation are introduced into XLCT iteration reconstruction so as to reduce ill conditioning of reconstruction. According to the CT and X-ray luminescence computed dual-mode synchronous tomography method, synchronous tomography of CT / XLCT can be achieved, dual-mode tomography processes are simplified, the experimental difficulty is reduced, the imaging time is reduced, the experimental failure rate is decreased, a radiation dosage is decreased, an error caused by objecting moving in the imaging process is avoided, and image registration and fusion difficulties are reduced.

Description

technical field [0001] The invention belongs to the interdisciplinary fields of physics mathematics, biomedical engineering and computer, and in particular relates to a dual-mode synchronous tomographic imaging method of CT and X-ray excited fluorescence. Background technique [0002] X-ray computed tomography (Computed Tomography, CT) has been widely used in small animal high-resolution anatomical structure imaging, but due to the lack of biomolecular imaging information, the application field is limited. In recent years, with the development of X-ray nanofluorescent probes, X-ray Luminescence Computed Tomography (XLCT), as a new method of molecular tomography that combines X-ray and optical imaging, is expected to realize deep tumor In vivo position marking, tracking and judgment of tumor size. CT / XLCT dual-mode imaging, both of which rely on X-rays, the former can provide information on the anatomical structure of small animals, and the latter can provide image informati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61B6/00
CPCA61B6/00A61B6/4417A61B6/482A61B6/5241
Inventor 戎军艳卢虹冰高鹏廖琪梅刘文磊刘洋见伟平
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com