Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method
A compound traditional Chinese medicine and transdermal drug delivery technology, applied in the field of traditional Chinese medicine, can solve the problems of short sustained release time, small drug storage, and achieve the effects of no toxic side effects, quick effect, and improved drug loading efficiency
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[0031] Example 1
[0032] Such as Figure 1-4 As shown, the substrate 2 is located in the middle of the ointment blank sticker and the ointment back sticker. The front surface of the substrate is laser-etched and a number of microneedles 6 are formed on the surface. These microneedles 6 form a group of rectangular microneedles on the substrate 2. Array. The substrate 2 is made of porous silicon material with a porous structure. The tip of the microneedle 6 is provided with a spike 5, the microneedle 6 is vertically fixed on the substrate 2, and there is a microneedle gap 7 between the microneedles 6, and the medicine is stored in the microneedle. In the gap 7 and the porous structure, the back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the plaster blank, the inner surface of the plaster back 3 covers the front of the substrate 2, and the inner surface of the plaster blank The surface 1 and the inner surface of the ointment back p...
Example Embodiment
[0033] Example 2
[0034] In this embodiment, the material used for the substrate 2 is porous polystyrene, and the substrate 2 has a porous structure. The front surface of the substrate is subjected to a laser-etching method and a lot of microneedles 6 are formed on the surface of the substrate 2. A group of rectangular microneedle arrays. The microneedle array is formed by arranging a plurality of microneedles 6 in sequence. The tip of the microneedles 6 is provided with a spiked part 5, and the microneedle array is vertically fixed on the substrate 2. There is a microneedle gap 7 between the microneedle gap 7 and the medicament is stored in the microneedle gap 7 and the porous structure. The back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the plaster blank paste, and the plaster back paste 3 covers the substrate 2 On the front, the inner surface 1 of the ointment blank paste and the ointment back paste 3 are compatible in size an...
Example Embodiment
[0035] Example 3
[0036] In Example 3, the material used for the substrate 2 is a porous titanium material. The substrate 2 has a porous structure. The front of the substrate 2 is provided with a microneedle array. The microneedle array is composed of a plurality of microneedles 6 arranged in sequence. There is a spiked part 5 at the top of the tube. The size of the spiked part 5 can be realized by adjusting the precision of laser-etching according to actual needs. The microneedle array is vertically fixed on the substrate 2 with a microneedle gap 7 between the microneedles 6. Stored in the microneedle gap 7 and the porous structure, the back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the ointment blank paste, and the inner surface of the ointment back paste 3 covers the front surface of the substrate 2. The inner surface 1 of the blank sticker and the inner surface of the ointment back sticker are fixedly connected by pasting. Th...
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