A kind of preparation method of p-aminophenylacetic acid
A technology of p-aminophenylacetic acid and p-nitrophenylacetic acid, applied in the field of p-aminophenylacetic acid preparation, can solve the problems of difficult solid waste, low product yield, backward process, etc., and achieves good purity, high yield, cost reduction effect
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Embodiment 1
[0022] A preparation method for p-aminophenylacetic acid, comprising the steps of: mixing water, ferric chloride, and p-nitrophenylacetic acid, heating up to 60°C under a nitrogen atmosphere, adding an aqueous solution of hydrazine hydrate dropwise, keeping the temperature for 2 hours, and cooling down to 20°C. ℃ to crystallize, filter to take the filter cake, wash with water, and dry to obtain p-aminophenylacetic acid, wherein the weight ratio of water, ferric chloride, p-nitrophenylacetic acid, and hydrazine hydrate is 10:0.05:1:0.45, wherein, for The amount of water used to wash the filter cake is not included.
Embodiment 2
[0024] A preparation method for p-aminophenylacetic acid, comprising the steps of: mixing water, ferric chloride, and p-nitrophenylacetic acid evenly, heating up to 90°C under a nitrogen atmosphere, adding an aqueous solution of hydrazine hydrate dropwise, keeping the temperature for 1 hour, and cooling down to 5 ℃ to crystallize, filter to take the filter cake, wash with water, and dry to obtain p-aminophenylacetic acid, wherein the weight ratio of water, ferric chloride, p-nitrophenylacetic acid, and hydrazine hydrate is 10:0.2:1:1, wherein, for The amount of water used to wash the filter cake is not included.
Embodiment 3
[0026] A preparation method for p-aminophenylacetic acid, comprising the steps of: mixing water, ferric chloride, and p-nitrophenylacetic acid, heating up to 70°C under a nitrogen atmosphere, adding hydrazine hydrate aqueous solution dropwise, keeping the temperature for 1.8h, and cooling down to Crystallize at 15°C, filter the filter cake, wash with water, and dry to obtain p-aminophenylacetic acid, wherein the weight ratio of water, ferric chloride, p-nitrophenylacetic acid, and hydrazine hydrate is 10:0.2:1:0.55, wherein, use The amount of water used to wash the filter cake is not included.
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