Synthetic method of medicine raw material namely 5-fluoro-2-bromoisonicotinic acid
A synthesis method and isonicotinic acid technology, applied in directions such as organic chemistry, can solve problems such as the synthesis method of unreported compounds, and achieve the effect of simple synthesis method and safe operation
Inactive Publication Date: 2016-11-16
WUXI QIANHAO BIOPHARMA
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Problems solved by technology
[0002] 5-Fluoro-2-bromoisonicotinic acid is the starting material for the synthesis of many drugs, especially the important intermediates of many pyridine compounds. There is no report on the synthesis method of this compound in China.
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[0008] The synthetic method of pharmaceutical raw material 5-fluoro-2-bromoisonicotinic acid of the present invention is specifically as follows:
[0009] Using 2,5-dibromopyridine as raw material, 5-fluoro-2-bromopyridine is prepared by displacement method under the action of certain solvent and catalyst, and then further undergoes hydroxylation to generate 5-fluoro-2-bromoisonicotinic acid. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.
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The invention relates to a method for synthesizing 5-fluoro-2-bromoisonicotinic acid as a raw material for medicine. Using 2,5-dibromopyridine as a raw material, 5-fluoro-2- Bromopyridine is then further hydroxylated to generate 5-fluoro-2-bromoisonicotinic acid. The synthesis method of the pharmaceutical raw material 5-fluoro-2-bromoisonicotinic acid of the present invention is simple, efficient, safe in operation and very practical in specific production.
Description
technical field [0001] The invention relates to a method for synthesizing 5-fluoro-2-bromoisonicotinic acid as a medical raw material. Background technique [0002] 5-Fluoro-2-bromoisonicotinic acid is the starting material for the synthesis of many drugs, especially the important intermediates of many pyridine compounds. There is no report on the synthesis method of this compound in China. Contents of the invention [0003] The object of the present invention is to overcome the above-mentioned disadvantages and provide a simple, efficient and safe synthetic method for the raw material 5-fluoro-2-bromoisonicotinic acid. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing 5-fluoro-2-bromoisonicotinic acid as a medical raw material, using 2,5-dibromopyridine as a raw material, and using a displacement method to prepare 5-fluoro-2-bromopyridine under the action of a certain solvent and a catalyst, Then further through hydr...
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IPC IPC(8): C07D213/803C07D213/79
CPCC07D213/803C07D213/79
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
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