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Synthetic method of medicine intermediate namely 2-hydroxy morpholine hydrochloride

A technology of hydroxymorpholine hydrochloride and synthesis method, applied in directions such as organic chemistry, can solve problems such as synthesis methods of unreported compounds, and achieve the effect of simple synthesis method and safe operation

Inactive Publication Date: 2016-11-16
WUXI QIANHAO BIOPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] 2-Hydroxymorpholine hydrochloride is the starting material for the synthesis of many drugs, especially the important intermediate of many hydrochloride compounds. There is no report on the synthesis method of this compound in China

Method used

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Examples

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Embodiment Construction

[0008] The synthetic method of the pharmaceutical intermediate 2-hydroxymorpholine hydrochloride of the present invention is specifically as follows:

[0009] Using hydrochloride as a raw material, it reacts with morphine at a temperature of 100°C-130°C under the action of solvent acetone, and then generates 2-hydroxymorpholine hydrochloride through methylation. The purity of this crude product can meet general reaction requirements and can be directly put into the reaction.

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Abstract

The invention relates to a synthesis method of a pharmaceutical intermediate 2-hydroxymorpholine hydrochloride, using hydrochloride as a raw material, under the action of solvent acetone, first reacting with morphine at a temperature of 100°C-130°C, and then passing methyl into 2-hydroxymorpholine hydrochloride. The synthesis method of the pharmaceutical intermediate 2-hydroxymorpholine hydrochloride of the present invention is simple, efficient and safe in operation, and is very practical in specific production.

Description

Technical field [0001] The invention relates to a method for synthesizing pharmaceutical intermediate 2-hydroxymorpholine hydrochloride. Background technique [0002] 2-Hydroxymorpholine hydrochloride is the starting material for the synthesis of many drugs, especially important intermediates for many hydrochloride compounds. There is currently no report on the synthesis method of this compound in China. Summary of the invention [0003] The purpose of the present invention is to overcome the above-mentioned shortcomings and provide a simple, efficient and safe operation method for the synthesis of pharmaceutical intermediate 2-hydroxymorpholine hydrochloride. [0004] The purpose of the present invention is achieved as follows: [0005] A method for synthesizing pharmaceutical intermediate 2-hydroxymorpholine hydrochloride. It uses hydrochloride as a raw material and reacts with morphine at a temperature of 100℃-130℃ under the action of solvent acetone, and then generates 2 through ...

Claims

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Application Information

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IPC IPC(8): C07D265/32
CPCC07D265/32
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
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