Application of agastache rugosus volatile oil to suppression of growth of drug-resistant escherichia coli

A technology of Escherichia coli and volatile oil, applied in the directions of essential oils/spices, antibacterial drugs, and fat production, it can solve the problems of blocking or solving drug resistance problems, and the speed cannot catch up with bacteria, so as to reduce the fatality rate and solve drug-resistant infections. Effect

Active Publication Date: 2016-11-23
XINJIANG MEDICAL UNIV
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Problems solved by technology

In fact, controlling the use of antibacterial drugs can only alleviate bacterial resistance, but cannot fundamentally block or solve the problem of drug resis

Method used

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  • Application of agastache rugosus volatile oil to suppression of growth of drug-resistant escherichia coli
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  • Application of agastache rugosus volatile oil to suppression of growth of drug-resistant escherichia coli

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Embodiment 1

[0020] 1. Extraction and yield determination of Volatile oil of Huoxiang planted in Xinjiang:

[0021] After separating the picked parts of the Huoxiang flower grown in Xinjiang and drying in the shade, take 100 g into a 5000 ml decanter, add less than 3500 ml of water, and soak for 1 hour. The volatile oil was extracted according to Appendix XD of "Chinese Pharmacopoeia" 2005 Edition (Part One) by steam distillation, and the extraction was carried out for 6-8 hours. Since the obtained distillate contains a small amount of water, add a little sodium chloride and store it in the refrigerator for 24 hours to separate the water and oil phases, and then separate them with a separatory filter to obtain a yellow, transparent, and dense The aromatic liquid, that is, the volatile oil of the Huoxiang flower planted in Xinjiang, the calculated volatile oil yield is 0.29% (w / w). By capillary specific gravity method, the density of the volatile oil of the Huoxiang flower planted in Xinjiang...

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Abstract

The invention discloses application of agastache rugosus volatile oil to suppression of growth of drug-resistant escherichia coli. A single chemical component, i.e. pulegone, is obtained from an agastache rugosus volatile oil to achieve a better in vitro suppression effect on the growth of human-derived drug-resistant escherichia coli, i.e. human-derived ESBLs-producing escherichia coli. The application has the beneficial effects that the first research on the effect of the agastache rugosus volatile oil on the drug-resistant escherichia coli finds that the growth of the drug-resistant escherichia coli can be suppressed; a main component serving as a drug-resistant suppressing agent is screened from the agastache rugosus volatile oil and then researched; data show that the main monomer component, i.e. the pulegone, of the agastache rugosus volatile oil can suppress the growth of the ESBLs-producing escherichia coli and affect the formation of a biofilm so as to relieve or avoid the drug-resistant infection of the escherichia coli and reduce the fatality rate; a new idea is brought up to solve and treat the human-derived ESBLs-producing escherichia coli; and the application has a great research significance.

Description

Technical field [0001] The invention relates to the technical field of application of Chinese medicine extracts, in particular to the application of the volatile oil of Agastache vulgaris in inhibiting the growth of drug-resistant Escherichia coli. Background technique [0002] At present, bacterial drug resistance has become a serious public health threat and a clinical problem that the world is concerned about. The emergence of drug-resistant bacteria makes the clinical efficacy of existing antibacterial drugs continue to decline, and the range of drug options is becoming more and more limited. In fact, controlling the use of antimicrobial drugs can only alleviate the resistance of bacteria, but cannot fundamentally block or solve the problem of resistance. This requires people to continue to develop new antibiotics, but the speed of developing new antibiotics is far behind the speed at which bacteria develop resistance. Traditional Chinese medicine, as the crystallization of ...

Claims

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Application Information

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IPC IPC(8): A61K36/532A61K31/122C11B9/02A61P31/04A61K133/00
CPCA61K31/122A61K36/532A61K2236/331C11B9/022C11B9/027Y02A50/30
Inventor 宫海燕张晨田树革陈凯李劭昱王学涵
Owner XINJIANG MEDICAL UNIV
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