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Melatonin secretion regulator, and method for regulating melatonin secretion

A method for regulating melatonin and a technology for melatonin are applied in the field of melatonin secretion regulator and melatonin secretion regulation, which can solve the problems of early start of the rise of melatonin secretion and the like.

Inactive Publication Date: 2016-11-23
KYUSHU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unknown that the start of the rise in melatonin secretion is brought forward by the intake of ornithine or its salt.

Method used

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  • Melatonin secretion regulator, and method for regulating melatonin secretion

Examples

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Effect test

Embodiment 1

[0090] CBA / N mice (male, 7-week-old, average body weight 20 to 30 g) were used in the test. Lighting conditions were set to a light-dark cycle of 12-h light period and 12-h dark period. The animals were reared under the conditions of room temperature 25±1° C., free access to water and food, and group feeding of 4 animals in each cage. The solution or distilled water administered to each group was prepared according to the following 1) to 3).

[0091] 1) Solution for 1000mg / kg administration group

[0092] L-Ornithine hydrochloride so as to be administered in an amount of 1000 mg / kg body weight was dissolved in distilled water having a volume converted to 10 mL per 1 kg of administered mice to prepare a solution for the 1000 mg / kg administered group.

[0093] 2) Solution for 3000mg / kg administration group

[0094] L-Ornithine hydrochloride so that the dose would be 3,000 mg / kg body weight was dissolved in distilled water at a volume converted to 10 mL per 1 kg of the mice to b...

manufacture example 1

[0100] [Manufacture Example 1] Manufacture of ornithine-containing tablet

[0101] 10.0 g of ornithine hydrochloride (product name: L-ornithine hydrochloride, manufactured by Kyowa Hakka Biochemical Co., Ltd.), 90.0 g of lactose, 2.0 g of dried cornstarch, 1.8 g of talc, and 0.2 g of magnesium stearate The ingredients were mixed evenly, and the mixture was compressed with a single-punch tablet machine to obtain tablets with a diameter of 5 mm and a weight of 15 mg.

manufacture example 2

[0102] [Manufacture Example 2] Manufacture of ornithine-containing granules

[0103] The tablet obtained in Production Example 1 was pulverized, granulated, and sieved to obtain 20-50 mesh granules.

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Abstract

The problem of the present invention is to provide a melatonin secretion regulator capable of regulating melatonin secretion in vivo; this problem is solved by providing a melatonin secretion regulator containing ornithine or a salt thereof as an active ingredient.

Description

technical field [0001] The present invention relates to a melatonin secretion regulating agent containing ornithine or a salt thereof, a method for regulating melatonin secretion, ornithine or a salt thereof for regulating melatonin secretion, ornithine or a salt thereof for producing melatonin Application in hormone secretion regulators. Background technique [0002] L-ornithine is used as a food raw material for enhancing muscle synthesis, improving basal metabolism, and preventing obesity, mainly in the United States. In addition, in Europe, L-ornithine is used as a drug for improving liver damage in the form of L-ornithine L-aspartate. [0003] In addition, ornithine is known to have effects of improving sleepiness or wakefulness (Patent Document 1), improvement of cold symptoms (Patent Document 2), and promotion of eating activity and / or digestive tract activity (Patent Document 3). However, it is not known that the start of melatonin secretion increase is brought for...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P25/20A61P43/00
CPCA61K31/198A61P25/20A61P43/00
Inventor 安尾忍菱田幸宏秋月沙织根桥麻实神村彩子
Owner KYUSHU UNIV
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