Disease risk predication method and disease risk predication system

Abstract

The invention relates to a disease risk predication method and system. The method comprises the following steps of: S1, receiving input gene sequencing result information; analyzing the input gene sequencing result information to obtain all mutant gene information; S2, looking up disease gene mutant information of corresponding gene sites from a precision medical knowledge base according to the gene sites corresponding to the mutant gene information, so as to obtain at least one piece of disease gene mutant information; S3, matching each piece of the disease gene mutant information with all the disease gene mutant information to obtain the similarity of each piece of the mutant gene information, and all the disease gene mutant information; and S4, obtaining a risk predication table aiming at the gene sequencing result information according to the similarity of each piece of the mutant gene information, and all the disease gene mutant information. By analyzing an association relation of susceptibility genes, mutation sites, mutation types and diseases, disease risk predication is carried out on healthy people and general disease risk grade predication is provided; disease risks in the future are reduced.

Description

Technical field

[0001] The invention relates to a disease risk prediction method and system, belonging to the field of biological information technology. Background technique

[0002] According to the "Global Cancer Report 2014", the number of cancer incidences in China in 2012 was 3.065 million, accounting for about 1 / 5 of the global cancer incidence; the number of cancer deaths was 2.205 million, accounting for about a quarter of the global cancer deaths. Cancer is actually a genetic disease, and early detection is crucial to the survival rate of cancer treatment. For example, colorectal cancer is one of the common malignant tumors in China and the fourth leading cause of cancer death in China. The average lifetime risk of colorectal cancer in the Chinese population is 6%. Among them, 30% of colorectal cancer stems from genetic factors. People who have first-degree relatives (siblings, parents, or children) have colorectal cancer at twice the average risk of the population. ...

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