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Method for extracting aesculetin from caper euphorbia seeds

A kind of technology of echinacea B and Qianjinzi, which is applied in the field of medicine and can solve the problems of high purity and impossibility of industrialization

Inactive Publication Date: 2016-12-14
西安岳达生物科技股份有限公司
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Problems solved by technology

[0003] The purpose of the present invention is to provide a method for extracting teretin from Stephania chinensis, so as to solve the problems that cannot be industrialized and have high purity.

Method used

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  • Method for extracting aesculetin from caper euphorbia seeds
  • Method for extracting aesculetin from caper euphorbia seeds
  • Method for extracting aesculetin from caper euphorbia seeds

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Embodiment Construction

[0015] The method for extracting auretin from A. chinensis: take 3Kg Fructus chinensis, press oil to obtain filter residue, wash filter residue with 0.5L methanol, add 30L methanol, reflux for 3 hours, extract 3 times, after merging, depressurize at 85°C After concentrating to no alcohol, 1L of the concentrated solution was obtained, extracted once with 2.2L of petroleum ether, discarded the upper layer, and a small amount of precipitation in the lower layer of the aqueous phase, adjusted the pH to 9 with sodium hydroxide solution to make it completely dissolved, and dissolved it with 6L of ethyl acetate Extracted 3 times, then adjusted to neutral with dilute hydrochloric acid, extracted once with 0.8L ethyl acetate, combined ethyl acetate, concentrated under reduced pressure until no ethyl acetate was obtained to obtain 36g yellow powder, and then recrystallized with 700mL methanol to obtain 27.5g pure The content of Pincetrin B is 98%.

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Abstract

The invention discloses a method for extracting aesculetin from caper euphorbia seeds, belonging to the technical fields of medicine and the chemical industry. The content of aesculetin in a natural plant, i.e., ash bark, is low; however, the content of aesculetin in the raw material caper euphorbia seeds in the invention is high. Since the ash bark has low aesculetin content, traditional separation and extraction technology is difficult in producing aesculetin with purity of 98% or above and realizing high-yield industrial production at the same time. The invention provides the method for separating and extracting aesculetin from the caper euphorbia seeds; with the method, cost for industrial production is reduced, and the purity of aesculetin reaches the grade of a bulk drug; so the method improves production efficiency, and is green and environment-friendly in process and free of severe harm to environment.

Description

technical field [0001] The invention relates to a method for extracting aproteretin from the daughter of a daughter, and belongs to the technical fields of medicine and chemical industry. Background technique [0002] Aesculetin is derived from the bark of Aesculus Aesculus, the whole plant of Chicory in Compositae, Rubiaceae, and belongs to the coumarin class. Most of the domestic reports are isolated and extracted from Qinpi, but the content in Qinpi is relatively low and it is more difficult. And the content of echinacea B is about 0.6%-2% in Fructus Rhizome, the raw material adopted in the present invention is Fructus Rhizome, which solves the problem of low raw material content, and the process is simple, solves the problem of industrial production, and the purity reaches more than 98% at the same time API level. Peptide B is an antibacterial drug that can inhibit Shigella, can be used to treat acute bacillary dysentery, and has anti-asthma and expectorant effects, an...

Claims

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Application Information

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IPC IPC(8): C07D311/16
CPCC07D311/16
Inventor 奚文祥杜敏陈琳剑杨晓莉张天
Owner 西安岳达生物科技股份有限公司
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