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Traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma), preparation method and application

A technology for variant asthma and granules, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problem of no granule preparation method, etc.

Inactive Publication Date: 2017-02-22
北京东方运嘉科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no record of the preparation method of granules for the original drug

Method used

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  • Traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma), preparation method and application
  • Traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma), preparation method and application
  • Traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma), preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Drug raw materials

[0041]

[0042] (2) Pharmaceutical excipients

[0043] Beta cyclodextrin 0.144g Mannitol 1.26g Carboxymethyl starch sodium 2.70g

[0044] Stevia 0.18g Dextrin amount (about 1.836g)

[0045] (3) Method

[0046] Soak perilla leaves and peucedanum in 9 times of water for 1 hour, extract volatile oil for 8 hours, collect volatile oil, add 4 times of water and 8 times of beta-cyclodextrin, grind, dry below 40°C, and crush into fine powder. into volatile oil beta-cyclodextrin inclusion compound, set aside. The distilled aqueous solution was collected in another device for later use.

[0047] Stir-fried burdock seeds, ground dragon, cicada slough, honey loquat leaves, fried perilla seeds and other five flavors, add water and cook three times, add 10 times the amount for the first time and cook for 1 hour, add 8 times the amount for the second time and cook for 1 hour, the third time Add 8 times the amount three times and decoct for 1 hour, filt...

Embodiment 2

[0051] (1) Drug raw materials

[0052]

[0053] (2) Pharmaceutical excipients

[0054] Beta cyclodextrin 0.176g Mannitol 0.98 Carboxymethyl starch sodium 2.91g

[0055] Stevia 0.19g Dextrin amount (about 1.836g)

[0056] (3) Method

[0057] Soak perilla leaves and peucedanum in 5 times of water for 0.5 hour, extract volatile oil for 5 hours, collect volatile oil, add 2 times of water and 4 times of beta-cyclodextrin, grind, dry below 40°C, crush into fine powder, and make into volatile oil beta-cyclodextrin inclusion compound, set aside. The distilled aqueous solution was collected in another device for later use.

[0058] Stir-fried burdock seeds, ground dragon, cicada slough, honey loquat leaves, fried perilla seeds and other five flavors, add water and boil three times, add 8 times the amount and cook for 1 hour for the first time, add 5 times the amount for 1 hour for the second time, and boil for 1 hour for the third time Add 5 times the amount three times and dec...

Embodiment 3

[0062] (1) Drug raw materials

[0063]

[0064] (2) Pharmaceutical excipients

[0065] Beta cyclodextrin 0.112g Mannitol 1.54g Carboxymethyl starch sodium 2.70g

[0066] Stevia 0.18g Dextrin amount (about 1.836g)

[0067] (3) Method

[0068] Soak perilla leaves and peucedanum with 12 times of water for 1 hour, extract volatile oil for 10 hours, collect volatile oil, add 6 times of water and 12 times of beta-cyclodextrin, grind, dry below 40°C, crush into fine powder, and make into volatile oil beta-cyclodextrin inclusion compound, set aside. The distilled aqueous solution was collected in another device for later use.

[0069] Stir-fried burdock seeds, ground dragon, cicada slough, honey loquat leaves, fried perilla seeds and other five flavors, add water and cook three times, add 10 times the amount for the first time and cook for 1 hour, add 8 times the amount for the second time and cook for 1 hour, the third time Add 8 times the amount three times and decoct for 1 ...

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Abstract

The invention discloses traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma) as well as a preparation method and an application of the traditional Chinese medicine granules. The traditional Chinese medicine granules comprise effective medicine components and pharmaceutically proper pharmaceutical excipients, wherein the traditional Chinese medicine raw materials for preparing the effective medicine components comprise 1-12 parts by weight of mix-fried ephedra, 1-12 parts by weight of perilla leaf, 1-12 parts by weight of earthworm, 1-12 parts by weight of prepared loquat leaf, 1-8 parts by weight of perilla fruit, 1-10 parts by weight of cicada slough, 1-10 parts by weight of hogfennel root, 1-12 parts by weight of great burdock achene and 1-10 parts by weight of Chinese magnoliavine fruit; the pharmaceutically proper pharmaceutical excipients comprise beta-cyclodextrin, mannitol, sodium carboxymethyl starch and dextrin.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule for treating post-cold cough and cough variant asthma and a preparation method thereof Background technique [0002] Cough variant asthma (Cough variant asthma, CVA), also known as insidious asthma or cough asthma, is a special type of asthma. Its particularity lies in the fact that it hardly has any symptoms of wheezing or dyspnea, so it is often missed, misdiagnosed, and mistreated. Many patients have been repeatedly and ineffectively used antibiotics and antitussive drugs for a long time, resulting in protracted aggravation of the condition. In recent years, with the gradual deepening of people's understanding of CVA, traditional Chinese medicine has achieved good results in the treatment of CVA. In traditional Chinese medicine writings, there is no disease name that exactly corresponds to CVA...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K36/79A61K9/16A61P11/14A61P11/06A61K35/62A61K35/64
CPCA61K9/1652A61K35/62A61K35/63A61K36/17A61K36/23A61K36/28A61K36/535A61K36/57A61K36/73A61K36/79A61K2236/333A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 晁恩祥晁燕曾风英
Owner 北京东方运嘉科技发展有限公司
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