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A group of peptides with analgesic effect and their pharmaceutical composition and application

A technology of composition and action, applied in the preparation of pharmaceutical compositions, peptides or their pharmaceutically acceptable salts, the field of novel peptides

Active Publication Date: 2019-04-02
唐琼瑶 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It is not yet known whether one or more amino acids in loop 3 (Loop 3) still have analgesic effect after deletion, substitution, or addition

Method used

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  • A group of peptides with analgesic effect and their pharmaceutical composition and application
  • A group of peptides with analgesic effect and their pharmaceutical composition and application
  • A group of peptides with analgesic effect and their pharmaceutical composition and application

Examples

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Embodiment Construction

[0028] In order to make the above objects, features and advantages of the present invention more obvious and comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0029] In the following description, many specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways than described here, and those skilled in the art can do similar By extension, the present invention is therefore not limited to the specific examples disclosed below.

[0030] Second, "one embodiment" or "an embodiment" referred to herein refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present invention. "In one embodiment" appearing in different places in this specification does not all refer to the same embodiment, nor is it a separate or selective embodiment that is ...

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Abstract

Disclosed are a group of peptides having an analgesic effect, and a pharmaceutical composition and the use thereof, wherein the peptides have the amino acid sequences as shown in SEQ ID No. 1 or SEQ ID No. 2 in the sequence listing, or pharmaceutically acceptable salts thereof. Also disclosed are polypeptides or pharmaceutically acceptable salts thereof, these still having an analgesic effect after one or more amino acids are deleted, substituted, or added in the amino acid sequences as shown in SEQ ID No. 1 or SEQ ID No. 2 in the sequence listing on the basis of cysteines being present at the N-terminus and C-terminus thereof. Polypeptides are formed after the deletion, substitution, or addition of one or more amino acids in Loop 3 of GsMTx-4, and then, the polypeptides are screened for a polypeptide having an analgesic effect. A short-chain series of polypeptides having an analgesic effect is confirmed by means of test results of the polypeptides with regard to a rat nociceptive pain model.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a group of novel peptides, in particular to peptides with analgesic effect or their pharmaceutically acceptable salts used in medicine. In addition, the present invention also relates to the use of the group of peptides in the preparation of pharmaceutical compositions. Background technique [0002] In 2000, Dr. Frederick Sachs of York State University successfully isolated the polypeptide GsMTx-4 from the venom of a Chilean tarantula (Chileantarantula) (Sachs F, et a., J Gen Physiol.115, Po583-598, 2000). The report pointed out that this is a polypeptide that has a specific inhibitory effect on mechanosensitive ion channels. GsMTx-4 was found to prevent congestive heart failure caused by cellular swelling, especially in the lungs, liver, and legs (Sachs F et al., JGP 2000). There are also reports that GsMTx-4 can inhibit atrial fibrillation in rabbits without affecting other ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A61K38/08A61P29/00
CPCA61K38/00C07K7/06
Inventor 唐琼瑶张赭柯少溪董平杜向荣唐明希李辉蒋昀杉吴奕洋
Owner 唐琼瑶
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