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Polypeptide P10581 and application thereof in preparation of medicine for relieving bone cancer pain

A bone cancer pain and drug technology, applied in the field of biomedicine, can solve the problems of poor analgesic effect, addiction and drug resistance of cancer pain

Pending Publication Date: 2021-06-11
THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many kinds of analgesic drugs for the pain of cancer patients clinically, among which morphine is the most commonly used and has the best analgesic effect, but morphine also has its obvious side effects and disadvantages, such as long-term use addiction, late tolerance Drug properties, and poor analgesic effect on some intractable cancer pain, etc.

Method used

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  • Polypeptide P10581 and application thereof in preparation of medicine for relieving bone cancer pain
  • Polypeptide P10581 and application thereof in preparation of medicine for relieving bone cancer pain
  • Polypeptide P10581 and application thereof in preparation of medicine for relieving bone cancer pain

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Synthesis of Peptide P10581

[0037] The polypeptide P10581 was artificially synthesized by conventional methods, and its amino acid sequence is shown in SEQ ID No.1;

[0038] SEQIDN0.1:

[0039] Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys.

[0040] According to the amino acid sequence shown, it was synthesized by Shanghai Sangon Bioengineering Co., Ltd., and a pure polypeptide P10581 with a purity of 98% was obtained.

Embodiment 2

[0042] The effect of polypeptide P10581 on bone cancer pain

[0043] 1. Experimental animals, instruments and materials

[0044] Select healthy juvenile and adult female SD rats with body weights of 90-100g and 180g-220g, respectively, and purchase them from the Experimental Animal Center of Xuzhou Medical University; after adapting to the measurement room for 2 hours, use the 38500-PAM pressure to measure the rat mechanical paw withdrawal threshold system ( Ugo Basile Biological Research Apparatus, Comerio–Varese, Italy) was aimed at the center of the plantar left hind foot of the rat, and the mechanical paw withdrawal threshold of the rat was measured at a constant force rate. In order to avoid damage to the rats, the maximum measurement time was set at 15s. If the paw withdrawal reflex did not appear after 15s, the measurement was stopped. Each rat was repeatedly measured 3-5 times (interval 5 min), and the average value was taken as the baseline pain threshold (Baseline,...

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Abstract

The invention relates to the technical field of biological medicines, and particularly discloses a polypeptide P10581 and application thereof in preparation of a medicine for relieving bone cancer pain, and the amino acid sequence of the polypeptide P10581 is as shown in SEQ ID N0.1. The polypeptide P10581 synthesized by the invention can effectively and stably relieve bone cancer pain.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a polypeptide P10581 and its use in preparing medicines for relieving bone cancer pain. Background technique [0002] The early pain of bone cancer is characterized by local pain, which is mostly persistent and gradually worsens, especially at night, affecting sleep. Taking general painkillers cannot relieve pain, and it can also involve pain in the tumor site and around the week. Bone metastasis of breast cancer refers to a disease characterized by bone damage and pain caused by the hematogenous metastasis of breast cancer cells to bone tissue. Common sites of breast cancer bone metastasis include the spine, pelvis, around the hip joint, and the backbone of long bones. Persistent back pain, limb numbness, muscle weakness, rib pain, cough, pleural effusion, etc. In severe cases, even aggravated bone pain, pathological fractures, vertebral body deformation, spinal cord compres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08A61K38/10A61P35/00A61P29/02A61P25/04
CPCC07K7/08A61P35/00A61P29/02A61P25/04A61K38/10
Inventor 唐明希唐琼瑶张赭刘苏陈晨马龙滕月甘军朱小霞阮思蓓凌凤
Owner THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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