5results about How to "Great clinical value" patented technology

The invention relates to preparation and application of a tumor radiotherapy embolism microsphere preparation capable of achieving CT imaging tracing. The microsphere is prepared by taking a polyvinyl alcohol derivative as a framework material, polymerizing, cross-linking and curing the polyvinyl alcohol derivative and an N-(aminoalkyl) methacrylamide hydrochloride monomer, and further covalently connecting a metal chelating agent and a CT imaging agent 2, 3, 5-triiodobenzaldehyde. The microsphere can mark radionuclides 111ln, 68Ga, Al18F, 64Cu, 177Lu and 90Y, embolism treatment and radionuclide internal irradiation treatment are combined, meanwhile, the microsphere CT tracing function is beneficial to monitoring the distribution condition of the microsphere in real time, and ectopic embolism is reduced.

The invention belongs to the technical field of cell bionic nano-drugs, and particularly discloses a cell bionic nano-particle as well as a construction method and application thereof. And performing simple ultrasonic fusion on the target cell membrane and the hydrophobic nano-core to obtain the cell bionic nano-particles. The bionic nano-cell can effectively inherit and simulate functional protein on the surface of a source cell membrane, systematically replace functions of the source cell in physiological and pathological processes, such as inflammatory factor adsorption, migration factor adsorption and the like, interfere and inhibit the disease process from the cellular mechanism, regulate and control cell composition and immune microenvironment of a focus part, and improve the immune function of the source cell membrane. The medicine does not need to be additionally carried. Aiming at the related pathogenesis of immune tolerance deficiency, the invention innovatively provides a therapeutic strategy for constructing immune tolerance. The homology and inherent immunosuppressive ability of tumor cells to the focus part of the autoimmune disease are reversely used, immune tolerance of the focus part based on immune checkpoints is reconstructed, meanwhile, target cells are replaced to adsorb autoimmune antibodies, and the immune response level is reduced.

The invention discloses an adjustable ultrasonic probe puncture supporting system which comprises a main body bracelet and an annular structural part capable of being opened and closed and used for installing and fixing an ultrasonic probe. The puncture needle pushing mechanism is arranged on the side wall of the main body bracelet and is used for pushing, puncturing and fixing a puncture needle; the puncture needle pushing mechanism comprises a puncture fixing frame, a pushing assembly and a locking assembly, the puncture fixing frame is fixedly connected to the outer wall of the main body bracelet, and the pushing assembly is arranged in the puncture fixing frame to install and fix a puncture needle and push the puncture needle; the locking assembly is arranged on the puncture fixing frame so as to lock or release the pushing function of the pushing assembly. Based on the ergonomics and the mechanical transmission principle, the puncture needle pushing mechanism and the ultrasonic probe are integrated, and the supporting system capable of being operated by one hand is designed. And a high-elasticity rubber material and a rotary gear mechanism are adopted, so that accurate propelling and stable fixing of the puncture needle are realized.

The present invention belongs to the technical field of cell bionic nanomedicines, and specifically discloses a cell bionic nanoparticle and a construction method and application thereof. Cell bionic nanoparticles are obtained by simple ultrasonic fusion of the target cell membrane and the hydrophobic nanocore. The bionic nanocell can effectively inherit and simulate the functional proteins on the surface of the source cell membrane, and systematically replace the functions played by the source cell in the physiological and pathological process, such as adsorbing inflammatory factors, migration factors, etc., interfering with and inhibiting the disease process from the cellular mechanism, regulating the cell composition and immune microenvironment of the lesion site, without relying on additional drug delivery. The present invention innovatively proposes a therapeutic strategy for constructing immune tolerance in response to the related pathogenesis of immune tolerance deficiency. The homology and inherent immunosuppression of tumor cells to the lesion site of autoimmune diseases are reversely used to reconstruct the immune tolerance of the lesion site based on immune checkpoints, while replacing the target cells to adsorb autoimmune antibodies and reduce the level of immune response.

This invention discloses a sonodynamic synergistic thrombolysis system and its application. The system includes a tissue plasminogen activator variant, a sonosensitive agent, and an ultrasound source. The tissue plasminogen activator variant is an intravenously administered formulation, the sonosensitive agent is an intravenously infused formulation, and the ultrasound source is used to emit ultrasound during sonosensitive agent administration to activate the agent. This invention significantly improves thrombolysis efficiency and reduces thrombolytic agent dosage and bleeding risk through the dual synergistic effect of TNK-tPA enzymatic hydrolysis and sonodynamic chemical oxidation. The system can significantly improve vascular recanalization rate and blood flow velocity recovery rate, and has high biocompatibility. This invention is applicable to thrombolytic treatment of various thrombotic diseases and has the advantages of simple operation, strong targeting, and wide application range.