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Medicine composition for treating acute hepatic failure

A technology for acute liver failure and composition, which is applied in the field of pharmaceutical composition for the treatment of acute liver failure, and can solve the problems of high price and insignificant effect

Inactive Publication Date: 2017-04-19
徐州诺克非医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some of these drugs are expensive, and some are not effective

Method used

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  • Medicine composition for treating acute hepatic failure
  • Medicine composition for treating acute hepatic failure
  • Medicine composition for treating acute hepatic failure

Examples

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Embodiment Construction

[0015] The above description is only an overview of the technical solution of the present invention. In order to understand the technical means of the present invention more clearly and implement it according to the content of the description and conventional technical means in the field, the animal test examples of the present invention will be further described in detail below .

[0016] The preparation method of the compound Dioxasampsone A involved in the present invention can be found in the literature (Dioxasampsone A and B, Two Polycyclic Polyprenylated Acylphloroglucinols with Unusual Epoxy-Ring-Fused Skeleton from Hypericum sampsonii Org. Lett., 2014, 16 (24), 6346-6349).

[0017] Pokeweed saponin D, CAS: 62640-05-5. Available from Leancare Ltd etc.

[0018] Modeling: Male mice with acute liver failure were selected, with a body weight of 100-140 g. The experimental animals were kept at a temperature of 22-25°C and a relative humidity of 45%-75%. Randomly divided in...

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Abstract

The invention discloses a medicine composition for treating acute hepatic failure. Active ingredients of the medicine composition comprise Dioxasampsone A, and also comprise esculentoside D. Through being metered by weight, the ratio of the Dioxasampsone A to the esculentoside D is (1:1) to (20:1). A good effect is achieved on the treatment of acute hepatic failure when the weight ratio of the Dioxasampsone A to the esculentoside D is (8 to 11):1.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating acute liver failure, belonging to the technical field of medicine. Background technique [0002] Acute liver failure (ALF) refers to a reversible condition in which a large number of hepatic cell apoptosis and necrosis suddenly occur in patients without previous chronic liver disease, and liver function is significantly abnormal, and rapidly progresses to hepatic encephalopathy in a short period of time (8 weeks). sex syndrome. Liver transplantation is currently the only effective clinical treatment. However, due to the shortage of donor livers, patients need to wait for a long time, and there are problems such as complicated postoperative complications after transplantation, and the extensive use of immunosuppressants and antibiotics. Although the development of liver transplantation in recent years has significantly increased the overall survival rate of acute liver failure, the mort...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K31/704A61P1/16
CPCA61K31/357A61K31/704A61K2300/00
Inventor 庄焕迪
Owner 徐州诺克非医药科技有限公司
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