Florfenicol water-soluble powder and preparation method thereof

A technology for water-soluble powder and florfenicol, which is applied in the field of florfenicol water-soluble powder and its preparation, can solve problems such as the inability of florfenicol to be completely water-soluble, and achieve the effects of improved water solubility and simple production process

Inactive Publication Date: 2017-05-31
SHANDONG BINZHOU ZHIYUAN BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the technical problem that the existing florfenicol cannot be completely water-soluble, the invention provides a water-soluble powder of florfenicol, which can be completely water-soluble, and the solubility at room temperature can reach 33.5%, and the aqueous solution is completely clarified

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A water-soluble powder of florfenicol, each 100g of water-soluble powder contains: 10g of florfenicol, 72g of water-soluble epichlorohydrin cross-linked beta cyclodextrin, and 18 g of hydroxypropyl beta cyclodextrin.

[0033] A preparation method of florfenicol water-soluble powder:

[0034] (1) Weigh 18g of hydroxypropyl betacyclodextrin, add 180ml of water, and stir to dissolve;

[0035] (2) Weigh 72g of water-soluble epichlorohydrin cross-linked beta cyclodextrin, add it to (1), stir to dissolve;

[0036] (3) Weigh 10 g of florfenicol, stir at room temperature for 30 minutes, and spray-dry the florfenicol to obtain the finished product.

Embodiment 2

[0038] A water-soluble powder of florfenicol, containing 15g of florfenicol, 74g of water-soluble epichlorohydrin cross-linked alpha cyclodextrin, and 11g of hydroxypropyl beta cyclodextrin in every 100g of water-soluble powder.

[0039] A preparation method of florfenicol water-soluble powder:

[0040] (1) Weigh 11g of hydroxypropyl betacyclodextrin, add 100ml of water, and stir to dissolve;

[0041] (2) Weigh 74g of soluble epichlorohydrin cross-linked alpha cyclodextrin, add it to (1), stir to dissolve;

[0042] (3) Weigh 15 g of florfenicol, stir at room temperature for 30 minutes, and spray-dry the florfenicol to obtain the finished product.

Embodiment 3

[0044] A water-soluble powder of florfenicol, each 100g of water-soluble powder contains: 15g of florfenicol, 70g of water-soluble epichlorohydrin cross-linked gamma cyclodextrin, and 15g of hydroxypropyl beta cyclodextrin.

[0045] A preparation method of florfenicol water-soluble powder:

[0046] (1) Weigh 5 g of hydroxypropyl betacyclodextrin, add 100 ml of water, and stir to dissolve;

[0047] (2) Weigh 35g of water-soluble epichlorohydrin cross-linked gamma cyclodextrin, add it to (1), stir to dissolve;

[0048] (3) Weigh 5 g of florfenicol, stir at room temperature for 30 minutes, and spray-dry the florfenicol to obtain the finished product.

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PUM

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Abstract

The invention relates to florfenicol water-soluble powder and a preparation method thereof. The water-soluble powder is prepared from the following raw materials in parts by weight: 5-20 parts of florfenicol, 25-95 parts of water-soluble cyclodextrin polymer (CDP) and 5-19 parts of hydroxypropyl beta-cyclodextrin. The powder can be completely dissolved into water, the room-temperature solubility can reach 33.5% and the water solution is completely clear. The room-temperature solubility can reach 33.5% (335,000ppm), and the effective content of the florfenicol can reach 15% (150,000ppm), and is about 3300 times of state-recommended clinical dosage and much higher than that of an existing florfenicol composition.

Description

Technical field [0001] The invention relates to a water-soluble florfenicol powder and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. Background technique [0002] Florfenicol, also known as fluprofen, thiamphenicol, Chinese name: [R--(R1.T)-2,2-dichloro-N-{(fluoromethyl)-2-hydroxy- 2-[4-(Methylsulfonyl)ethyl]acetamide is a new type of chloramphenicol broad-spectrum antibacterial drug developed by Schering-Plough, USA, and belongs to the second-class new drug in my country. It was first marketed in Japan in 1990. It was also approved as a feed additive for pigs in Japan and Mexico to prevent and treat bacterial diseases in pigs. The drug has a strong bactericidal effect, is not easy to develop drug resistance, and has no cross-resistance with other drugs. . However, florfenicol has poor water solubility, which seriously affects its bioavailability. [0003] Florfenicol is almost insoluble in water, and the inclusion solubility in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/69A61P31/04
CPCA61K9/146A61K31/165
Inventor 李媛媛申健张荣鹏陈晋波
Owner SHANDONG BINZHOU ZHIYUAN BIO TECH CO LTD
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