A kind of aluminum-magnesium-pirin tablet (ii) and preparation technology thereof

A technology for aluminum-magnesium pirin tablets and aspirin, which is applied in the field of aluminum-magnesium pirin tablets and their preparation, can solve the problems of slow dissolution of aluminum-magnesium pirin tablets, rising impurities, and risk of affecting consistency, and achieves inhibition of platelet adhesion and prevention. Aggregation, avoidance of irritation and damage, efficacy of medication safety

Active Publication Date: 2019-10-15
中健康桥医药集团股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, in the early stage of research, it was found that the dissolution of Al-Mg-Pirin Tablets (II) was slower in the standard medium (0.1M hydrochloric acid), and the impurities in related substances had a significant upward trend, which directly affected the consistency and BE. risk of experimentation

Method used

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  • A kind of aluminum-magnesium-pirin tablet (ii) and preparation technology thereof
  • A kind of aluminum-magnesium-pirin tablet (ii) and preparation technology thereof
  • A kind of aluminum-magnesium-pirin tablet (ii) and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] An aluminum-magnesium-pirin tablet (II), made of an aspirin layer and a buffer laminate, wherein the aspirin layer is made of the following raw materials: 81g of aspirin, 40.88g of mannitol, 10g of cornstarch, 0.85g of tartaric acid, Gelatin 0.12g, lemon yellow aluminum lake 0.05g, silicon dioxide 1.1g; The buffer layer is made of the following raw materials: aluminum glycolate 11g, heavy magnesium carbonate 22g, mannitol 30g, cornstarch 29.85g, Gelatin 0.15g, silicon dioxide 1g.

[0041] The preparation technology of this aluminum-magnesium-pirin tablet (II) adopts the following steps:

[0042] (1) get above-mentioned raw material aspirin of aspirin layer, tartaric acid and mannitol, cross 80 mesh sieves after being pulverized respectively; Get above-mentioned raw material cornstarch of aspirin layer, cross 80 mesh sieves, get aspirin powder, tartaric acid powder, mannitol powder and cornstarch A ,spare;

[0043] (2) get the gelatin of above-mentioned weight of aspir...

Embodiment 2

[0054] An aluminum-magnesium-pirin tablet (II), made of an aspirin layer and a buffer laminate, wherein the aspirin layer is made of the following raw materials: 81 g of aspirin, 38 g of mannitol, 8 g of cornstarch, 0.6 g of tartaric acid, and gelatin 0.1g, tartrazine aluminum lake 0.03g, silicon dioxide 0.9g; The buffer layer is made of the following raw materials: aluminum glycolate 11mg, heavy magnesium carbonate 22g, mannitol 28g, cornstarch 27g, gelatin 0.12 g, silicon dioxide 0.8g.

[0055] The preparation technology of this aluminum-magnesium-pirin tablet (II) adopts the following steps:

[0056] (1) get above-mentioned raw material aspirin of aspirin layer, tartaric acid and mannitol, cross 80 mesh sieves after being pulverized respectively; Get above-mentioned raw material cornstarch of aspirin layer, cross 80 mesh sieves, get aspirin powder, tartaric acid powder, mannitol powder and cornstarch A ,spare;

[0057] (2) Get the gelatin of the above-mentioned weight of ...

Embodiment 3

[0068] An aluminum-magnesium-pirin tablet (II), made of an aspirin layer and a buffer laminate, wherein the aspirin layer is made of the following raw materials: 81 g of aspirin, 42 g of mannitol, 12 g of cornstarch, 1.0 g of tartaric acid, and gelatin 0.14g, lemon yellow aluminum lake 0.07g, silicon dioxide 1.3g; The buffer layer is made of the following raw materials: aluminum glycolate 11g, heavy magnesium carbonate 22g, mannitol 32g, cornstarch 31g, gelatin 0.18 g, silicon dioxide 1.2g.

[0069] The preparation technology of this aluminum-magnesium-pirin tablet (II) adopts the following steps:

[0070] (1) get above-mentioned raw material aspirin of aspirin layer, tartaric acid and mannitol, cross 80 mesh sieves after being pulverized respectively; Get above-mentioned raw material cornstarch of aspirin layer, cross 80 mesh sieves, get aspirin powder, tartaric acid powder, mannitol powder and cornstarch A ,spare;

[0071] (2) get the gelatin of above-mentioned weight of a...

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Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to an aluminum, magnesium and aspirin tablet (II) and a preparing method thereof. The aluminum, magnesium and aspirin tablet (II) is made by tableting an aspirin layer and a buffering layer, and the aspirin layer is prepared from aspirin, mannitol, corn starch, tartaric acid, gelatin, tartrazine aluminum lake and silicon dioxide; the buffering layer is prepared from dihydroxyaluminium aminoacetate, heavy magnesium carbonate, mannitol, corn starch, gelatin and silicon dioxide. The aluminum, magnesium and aspirin tablet (II) prepared from the preparing technology has a better dissolution rate, and the impurities are obviously lowered compared with an impurity index in an existing product.

Description

[0001] (1) Technical field [0002] The invention belongs to the technical field of pharmacy, and particularly relates to an aluminum-magnesium-pirin tablet (II) and a preparation process thereof. [0003] (2) Background technology [0004] Aluminum-magnesium-pirin tablets were first developed and marketed in Japan by LION in 2001, with the product name BUFFERIN. Among them, the low-dose specification is marketed as an anti-platelet agent. [0005] Aspirin, the main component of aluminum-magnesium pirin tablets, is also known as acesalicylic acid and acetylsalicylic acid. It has been developed for more than 100 years. In the extensive medical practice all over the world, it has gradually been found that it is not only an antipyretic and analgesic, but also an antipyretic and analgesic. It can also treat many diseases, and it is still a special medicine for some diseases. Aspirin has become the latest effective therapy for cardiovascular disease. The medical profession genera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/36A61K47/42A61K33/10A61P9/10A61K31/616A61K31/198
Inventor 刘宗杰
Owner 中健康桥医药集团股份有限公司
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